Parthenin

Parthenin
Names
	IUPAC name 1-Hydroxy-6β,12-epoxyambrosa-2,11(13)-diene-4,12-dione
	Systematic IUPAC name (3aS,6S,6aS,9aS,9bR)-6a-Hydroxy-6,9a-dimethyl-3-methylidene-3,3a,4,5,6,6a,9a,9b-octahydroazuleno[4,5-b]furan-2,9-dione
	Other names Parthenicin
Identifiers
CAS Number	508-59-8;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:7938;
ChEMBL	ChEMBL401149;
ChemSpider	390756;
KEGG	C09523;
PubChem CID	442288;
UNII	982DJP4W6A;
CompTox Dashboard (EPA)	DTXSID40877834 ;
	InChI InChI=1S/C15H18O4/c1-8-4-5-10-9(2)13(17)19-12(10)14(3)11(16)6-7-15(8,14)18/h6-8,10,12,18H,2,4-5H2,1,3H3/t8-,10-,12+,14-,15+/m0/s1 Key: LLQCRTZROWMVOL-JISBIHODSA-N;
	SMILES C[C@H]1CC[C@@H]2[C@H]([C@]3([C@]1(C=CC3=O)O)C)OC(=O)C2=C;
Properties
Chemical formula	C15H18O4
Molar mass	262.305 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Parthenin is a chemical compound classified as a sesquiterpene lactone. It has been isolated from Parthenium hysterophorus.

It is genotoxic, allergenic, and an irritant.^[1] Parthenin is believed to be responsible for the dermatitis caused by Parthenium hysterophorus.^[2]

References

↑ Ramos, Alberto; Rivero, Reinaldo; Visozo, Angel; Piloto, Janet; Garcı́a, Arilia (2002). "Parthenin, a sesquiterpene lactone of Parthenium hysterophorus L. Is a high toxicity clastogen". Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 514 (1–2): 19–27. Bibcode:2002MRGTE.514...19R. doi:10.1016/S1383-5718(01)00321-7. PMID 11815241.
↑ Picman, J.; Picman, A. K. (1985). "Treatment of dermatitis from parthenin". Contact Dermatitis. 13 (1): 9–13. doi:10.1111/j.1600-0536.1985.tb02484.x. PMID 4042647. S2CID 40846706.

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[1] Ramos, Alberto; Rivero, Reinaldo; Visozo, Angel; Piloto, Janet; Garcı́a, Arilia (2002). "Parthenin, a sesquiterpene lactone of Parthenium hysterophorus L. Is a high toxicity clastogen". Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 514 (1–2): 19–27. Bibcode:2002MRGTE.514...19R. doi:10.1016/S1383-5718(01)00321-7. PMID 11815241.

[2] Picman, J.; Picman, A. K. (1985). "Treatment of dermatitis from parthenin". Contact Dermatitis. 13 (1): 9–13. doi:10.1111/j.1600-0536.1985.tb02484.x. PMID 4042647. S2CID 40846706.

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References