PRPSAP1

PRPSAP1
Identifiers
Aliases	PRPSAP1, PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1, phosphoribosyl pyrophosphate synthetase associated protein 1
External IDs	OMIM: 601249; MGI: 1915013; HomoloGene: 55687; GeneCards: PRPSAP1; OMA:PRPSAP1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C4K
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,384,521 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,385,028 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; right lobe of thyroid gland; ; gonad; ; minor salivary glands; ; left lobe of thyroid gland; ; left testis; ; right testis; ; right lung; ; ventricular zone; ; right adrenal cortex;
	Top expressed in
	Paneth cell; ; internal carotid artery; ; epithelium of lens; ; external carotid artery; ; duodenum; ; crypt of lieberkuhn of small intestine; ; endothelial cell of lymphatic vessel; ; left lobe of liver; ; condyle; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; ribose phosphate diphosphokinase activity; magnesium ion binding; protein binding; identical protein binding; enzyme regulator activity;
Cellular component	ribose phosphate diphosphokinase complex; cytoplasm;
Biological process	nucleotide biosynthetic process; nucleobase-containing compound metabolic process; negative regulation of catalytic activity; 5-phosphoribose 1-diphosphate biosynthetic process; purine nucleotide biosynthetic process; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	5635
	67763
	ENSG00000161542
	ENSMUSG00000015869
	Q14558
	Q9D0M1
	NM_002766; NM_001330503; NM_001366236
	NM_026364
	NP_001317432; NP_002757; NP_001353165
	NP_080640; NP_001391595; NP_001391596; NP_001391597; NP_001391598
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.
↑ "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID 7572345.
Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role". J. Biol. Chem. 269 (11): 8334–40. doi:10.1016/S0021-9258(17)37198-3. PMID 8132556.
Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39". Biochim. Biophys. Acta. 1306 (1): 27–30. doi:10.1016/0167-4781(96)00030-9. PMID 8611620.
Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions". Biochim. Biophys. Acta. 1342 (1): 28–36. doi:10.1016/s0167-4838(97)00077-0. PMID 9366267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8660991-5] Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.

[entrez-6] "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

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PRPSAP1

References

Further reading