PPFIA4

PPFIA4
Identifiers
Aliases	PPFIA4, PTPRF interacting protein alpha 4
External IDs	OMIM: 603145; GeneCards: PPFIA4; OMA:PPFIA4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,078,740 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; paraflocculus of cerebellum; ; right frontal lobe; ; primary visual cortex; ; Brodmann area 9; ; middle temporal gyrus; ; apex of heart; ; cingulate gyrus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; presynaptic active zone; cell surface; cytosol; synapse; intracellular anatomical structure;
Biological process	glutamate secretion; neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	8497
	n/a
	ENSG00000143847
	n/a
	O75335
	n/a
NM_001304331; NM_001304332; NM_015053; NM_001393950; NM_001393951;
	NM_001393952; NM_001393953; NM_001393954; NM_001393955; NM_001393956; NM_001393957
	n/a
	NP_001291260; NP_001291261
	n/a
	Wikidata
View/Edit Human

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.^[3]^[4]

Interactions

PPFIA4 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
↑ "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
1 2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
↑ Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
↑ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/s0896-6273(02)00640-2. PMID 11931740. S2CID 16142847.

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID 14612982.
Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9624153-3] Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.

[entrez-4] "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".

[pmid12923177-5] 1 2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.

[pmid12629171-6] Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.

[pmid11931740-7] Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/s0896-6273(02)00640-2. PMID 11931740. S2CID 16142847.

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PPFIA4

Interactions

References

Further reading