PHAX

PHAX
Identifiers
Aliases	PHAX, RNUXA, phosphorylated adaptor for RNA export
External IDs	OMIM: 604924; MGI: 1891839; HomoloGene: 10558; GeneCards: PHAX; OMA:PHAX - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XC7
Gene location (Human) Chr. Chromosome 5 (human) Band 5q23.2 Start 126,600,925 bp End 126,627,252 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 D3|18 30.63 cM Start 56,695,515 bp End 56,720,784 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon endothelial cell epithelium of colon ventricular zone ganglionic eminence stromal cell of endometrium smooth muscle tissue islet of Langerhans primary visual cortex Top expressed in otic placode saccule otic vesicle neural tube genital tubercle embryo abdominal wall neural layer of retina epiblast primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding toxic substance binding RNA binding Cellular component nucleoplasm Cajal body nucleus cytosol soma cytoplasm centrosome Biological process protein transport snRNA export from nucleus snRNA transcription by RNA polymerase II nuclear export Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51808 56698 Ensembl ENSG00000164902 ENSMUSG00000008301 UniProt Q9H814 Q9JJT9 RefSeq (mRNA) NM_032177 NM_001162989 NM_019996 RefSeq (protein) NP_115553 NP_001156461 NP_064380 Location (UCSC) Chr 5: 126.6 – 126.63 Mb Chr 18: 56.7 – 56.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Phosphorylated adapter RNA export protein is a protein that in humans is encoded by the PHAX gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Segref A, Mattaj IW, Ohno M (2001). "The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export". RNA. 7 (3): 351–60. doi:10.1017/S1355838201002278. PMC 1370092. PMID 11333016.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Boulon S, Verheggen C, Jady BE, et al. (2005). "PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli". Mol. Cell. 16 (5): 777–87. doi:10.1016/j.molcel.2004.11.013. PMID 15574332.
• Watkins NJ, Lemm I, Ingelfinger D, et al. (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl:11858/00-001M-0000-0012-EB89-8. PMID 15574333.