PEX11B

PEX11B
Identifiers
Aliases	PEX11B, PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta, PEX11beta
External IDs	OMIM: 603867; MGI: 1338882; HomoloGene: 2852; GeneCards: PEX11B; OMA:PEX11B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,918,717 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,552,682 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; internal globus pallidus; ; palpebral conjunctiva; ; cingulate gyrus; ; right frontal lobe; ; nucleus accumbens; ; anterior cingulate cortex; ; mucosa of transverse colon; ; caudate nucleus;
	Top expressed in
	spermatocyte; ; spermatid; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; lip; ; entorhinal cortex; ; primary visual cortex; ; perirhinal cortex; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity;
Cellular component	integral component of membrane; peroxisomal membrane; peroxisome; extracellular exosome; membrane; integral component of peroxisomal membrane; mitochondrion; protein-containing complex;
Biological process	regulation of peroxisome size; peroxisome organization; protein homooligomerization; signal transduction; peroxisome fission;
	Sources:Amigo / QuickGO
Orthologs
	8799
	18632
	ENSG00000131779
	ENSMUSG00000028102
	O96011
	Q9Z210
	NM_001184795; NM_003846
	NM_001162387; NM_001162388; NM_011069
	NP_001171724; NP_003837
	NP_001155859; NP_001155860; NP_035199
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.^[5]^[6] It is involved in the regulation of peroxisome abundance. ^[7]

Interactions

PEX11B has been shown to interact with PEX19.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131779 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028102 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.
↑ "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
↑ Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949. S2CID 33237347.
↑ Sacksteder KA, Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.
↑ Fransen M, Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.

Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID 9826565.
Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi:10.1074/jbc.M212031200. PMID 12618434.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131779 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9792670-5] Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.

[entrez-6] "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".

[pmid16218949-7] Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949. S2CID 33237347.

[pmid10704444-8] Sacksteder KA, Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.

[pmid11390669-9] Fransen M, Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.

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This page was redesigned at the edge.

PEX11B

Interactions

Related gene problems

References

Further reading