PDE7B

PDE7B
Identifiers
Aliases	PDE7B, bA472E5.1, phosphodiesterase 7B
External IDs	OMIM: 604645; MGI: 1352752; HomoloGene: 32194; GeneCards: PDE7B; OMA:PDE7B - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXW
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	136,195,574 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	20,600,824 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; Achilles tendon; ; external globus pallidus; ; nucleus accumbens; ; middle temporal gyrus; ; buccal mucosa cell; ; tibia; ; caudate nucleus; ; putamen; ; endothelial cell;
	Top expressed in
	olfactory tubercle; ; globus pallidus; ; olfactory epithelium; ; lateral geniculate nucleus; ; medial dorsal nucleus; ; nucleus accumbens; ; vas deferens; ; median eminence; ; medial geniculate nucleus; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity; phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding;
Cellular component	cytosol;
Biological process	cAMP catabolic process; signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27115
	29863
	ENSG00000171408
	ENSMUSG00000019990
	Q9NP56
	Q9QXQ1
	NM_018945
	NM_013875; NM_001347366
	NP_061818
	NP_001334295; NP_038903
	Wikidata
View/Edit Human	View/Edit Mouse

PDE7B is a mammalian gene that encodes a 3'5'-cyclic nucleotide phosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclic nucleotide signaling pathways.^[5]^[6] There are 21 PDE genes in mammals that are pharmacologically grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for cAMP relative to cGMP.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171408 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019990 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hetman, J.M., Soderling, S.H., Glavas, N.A., and Beavo, J.A. (2000). Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A 97, 472-476.
↑ Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171408 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019990 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Hetman, J.M., Soderling, S.H., Glavas, N.A., and Beavo, J.A. (2000). Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A 97, 472-476.

[6] Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583.

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References