PASD1
| PASD1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | PASD1, CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300993; HomoloGene: 131196; GeneCards: PASD1; OMA:PASD1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.[3][4][5]
PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.[6][7]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.
- ↑ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.
- ↑ "Entrez Gene: PASD1 PAS domain containing 1".
- ↑ Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.
- ↑ Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.
Further reading
[edit]- Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–1304. Bibcode:2005BBRC..335.1293G. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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