Metamizil
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| Drug class | muscarinic antagonist (anticholinergic drug); sedative and hypnotic |
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Metamizil is a central anticholinergic drug and a tranquilliser with powerful sedative and hypnotic effects; it was studied during the Soviet era by Soviet scientists alongside amizil.[1][2]
Pharmacology
[edit]Metamizil acts as a muscarinic antagonist[3][4] and, at a dose of 2 mg/kg, blocks the symptoms of parkinsonism (hypokinesia, rigidity and tremor). Metamizil was used as premedication,[5][6] and is a strong sedative.[2][7][5]
The median lethal dose following intraperitoneal administration was 118 mg/kg (mouse).[8]
Uses
[edit]It has been suggested that it be used in the treatment of neuroses in dogs and humans.[7][9] Sometimes as premedication (as a tranquilliser).[5][6] As well as in the treatment of vascular parkinsonism[10][11] and cerebral palsy.[12]
Side effects
[edit]The reported side effects included dizziness and a dry mouth.[11]
References
[edit]- ↑ Losev NA, Kamenetskiĭ VK (1985). "[Method of treating parkinsonism with metamizil in combination with galanthamine (clinico-experimental basis)]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova. 85 (3). Moscow: 376–381. PMID 3993298.
- 1 2 Borodkin Iu (1964). "[Effect of Amizil, Metamizil and Other Central Cholinolytics on the Convulsive Threshold of the Hippocampus and on the Threshold of the Activation Reaction]". Farmakologiia I Toksikologiia. 27: 651–654. PMID 14321282.
- ↑ Tkachenko EI, Losev NA (May 1983). "[Effect of N- and M- cholinoblockaders on experimental epileptogenesis]". Biulleten' Eksperimental'noi Biologii I Meditsiny. 95 (5): 23–25. PMID 6133569.
- ↑ Losev NA, Tkachenko EI (April 1986). "[Effect of N- and M-cholinergic-potentiating and cholinergic-blocking agents on the epileptogenesis of a penicillin focus in the dorsal hippocampus]". Biulleten' Eksperimental'noi Biologii I Meditsiny. 101 (4): 436–438. PMID 2870750.
- 1 2 3 Pratusevich Iu, Malomuzh FF, Denisenko PP (1962). "[Analysis of the mutual potentiation of the tranquilizing effect of aminazin and metamizil in tympanoplasty in children]". Vestnik Otorinolaringologii. 24: 44–50. PMID 13985983.
- 1 2 THE USE OF TRANQUILLISERS IN SURGERY (in Russian) Associate Professor I. A. Petukhov
- 1 2 Onisko OG (1982). "[Study of the therapeutic effect of metamizil in experimental neuroses in the dog]". Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova. 32 (4): 747–749. PMID 6890280.
- ↑ "Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)-1-methylethyl ester". PubChem. U.S. National Library of Medicine. Retrieved 2026-08-28.
- ↑ Denisenko PP, Pratusevich Iu (1963). "[On Tranquilizing Properties of 2 New Central Cholinolytics--Metamizil and Methyldiphacil--and Possible Application of Their Action]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova. 63. Moscow: 582–590. PMID 14064772.
- ↑ Kamenetskiĭ VK (September 1978). "[Combined administration of cholinolytic metamizil and L-Dopa in vascular parkinsonism]". Klinicheskaia Meditsina. 56 (9). Mosk: 113–115. PMID 703225.
- 1 2 Kamenetskiĭ VK (1978). "[Experience in treating vascular parkinsonism with metamysil]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova. 78 (3). Moscow: 365–370. PMID 645311.
- ↑ Shashurina VN (1965). "[Use of central (metamizil), peripheral (melliktin) cholinolytic and anticholinesterase (nivalin) preparations on combined therapy of cerebral paralysis in children]". Voprosy Psikhiatrii I Nevropatologii; Sbornik Trudov. 11: 257–263. PMID 5883063.