Map44
| mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MASP1 | ||||||
| Alt. symbols | CRARF, PRSS5 | ||||||
| NCBI gene | 5648 | ||||||
| HGNC | 6901 | ||||||
| OMIM | 600521 | ||||||
| RefSeq | NM_001879 | ||||||
| UniProt | P48740 | ||||||
| Other data | |||||||
| Locus | Chr. 3 q27-q28 | ||||||
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Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1]
See also
[edit]References
[edit]- ↑ Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S (December 2009). "MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation". Journal of Immunology. 183 (11): 7371–8. doi:10.4049/jimmunol.0902388. PMID 19917686.
External links
[edit]- MASP+Proteases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Pathways | |||||||
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| Activators/enzymes |
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| Inhibitors | |||||||
| Complement receptors | |||||||
| Function |
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