MZB1

MZB1
Identifiers
Aliases	MZB1, MEDA-7, PACAP, pERp1, marginal zone B and B1 cell specific protein
External IDs	OMIM: 609447; MGI: 1917066; HomoloGene: 12333; GeneCards: MZB1; OMA:MZB1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 139,387,467 bp End 139,390,081 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 B2 Start 35,780,320 bp End 35,782,420 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus spleen lymph node appendix rectum mucosa of transverse colon tonsil bone marrow cell trachea duodenum Top expressed in spleen ileum jejunum bone marrow colon thymus duodenum granulocyte embryo pharynx More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm extracellular region endoplasmic reticulum lumen endoplasmic reticulum endoplasmic reticulum chaperone complex Biological process integrin activation regulation of cell population proliferation positive regulation of cell population proliferation apoptotic process regulation of B cell proliferation regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51237 69816 Ensembl ENSG00000170476 ENSMUSG00000024353 UniProt Q8WU39 Q9D8I1 RefSeq (mRNA) NM_016459 NM_027222 RefSeq (protein) NP_057543 NP_081498 Location (UCSC) Chr 5: 139.39 – 139.39 Mb Chr 18: 35.78 – 35.78 Mb PubMed search
Wikidata
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Marginal zone B and B1 cell-specific protein is a protein that in humans is encoded by the MZB1 gene.

Further reading

• Zhang H, Chen S, Huang L (May 2012). "[Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer]". Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer. 15 (5): 287–93. doi:10.3779/j.issn.1009-3419.2012.05.07. PMC 6000130. PMID 22613335.
• Vaudry D, Rousselle C, Basille M, Falluel-Morel A, Pamantung TF, Fontaine M, Fournier A, Vaudry H, Gonzalez BJ (April 2002). "Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6398–403. Bibcode:2002PNAS...99.6398V. doi:10.1073/pnas.082112699. PMC 122960. PMID 11972030.
• Bonfoco E, Li E, Kolbinger F, Cooper NR (August 2001). "Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein". The Journal of Biological Chemistry. 276 (31): 29242–50. doi:10.1074/jbc.M100684200. PMID 11350957.
• Katoh M, Katoh M (July 2003). "MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues". International Journal of Oncology. 23 (1): 235–41. PMID 12792799.
• Zhang H, Chen X, Sairam MR (September 2011). "Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome". Diabetologia. 54 (9): 2368–80. doi:10.1007/s00125-011-2212-7. PMID 21688198.
• Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R (November 2010). "Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells". Immunity. 33 (5): 723–35. doi:10.1016/j.immuni.2010.11.013. PMC 3125521. PMID 21093319.
• Shimizu Y, Meunier L, Hendershot LM (October 2009). "pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin". Proceedings of the National Academy of Sciences of the United States of America. 106 (40): 17013–8. Bibcode:2009PNAS..10617013S. doi:10.1073/pnas.0811591106. PMC 2761359. PMID 19805157.
• van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I (October 2009). "Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1". Proceedings of the National Academy of Sciences of the United States of America. 106 (40): 17019–24. Bibcode:2009PNAS..10617019V. doi:10.1073/pnas.0903036106. PMC 2761347. PMID 19805154.
• Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J (July 2012). "Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma". Clinical Cancer Research. 18 (13): 3541–51. doi:10.1158/1078-0432.CCR-11-1007. PMID 22573353.