MTCL2

MTCL2
Identifiers
Aliases	MTCL2, C20orf117, KIAA0889, SOGA, suppressor of glucose, autophagy associated 1, SOGA1, microtubule crosslinking factor 2
External IDs	MGI: 2444575; GeneCards: MTCL2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	36,863,538 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,921,174 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; sural nerve; ; ganglionic eminence; ; cerebellar vermis; ; lower lobe of lung;
	Top expressed in
	lumbar subsegment of spinal cord; ; genital tubercle; ; tail of embryo; ; cerebellar cortex; ; ventricular zone; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; ascending aorta; ; otic vesicle; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	negative regulation of gluconeogenesis; insulin receptor signaling pathway; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	140710
	320706
	ENSG00000149639
	ENSMUSG00000055485
	O94964
	E1U8D0; A2ACV6
	NM_199181; NM_080627; NM_152257
	NM_001164663
	NP_542194; NP_954650
	NP_001158135
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule cross-linking factor 2 is a protein that in humans is encoded by the MTCL2 gene (previously SOGA1).^[5]^[6] This microtubule protein is involved in chromosome segregation.^[6] It has also been known as SOGA family member 1 or suppressor of glucose, autophagy-associated protein 1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149639 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055485 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
1 2 "Entrez Gene: C20orf117 chromosome 20 open reading frame 117".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149639 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055485 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[entrez-6] 1 2 "Entrez Gene: C20orf117 chromosome 20 open reading frame 117".

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MTCL2

References

Further reading