MOAP1

MOAP1
Identifiers
Aliases	MOAP1, MAP-1, PNMA4, modulator of apoptosis 1
External IDs	OMIM: 609485; MGI: 1915555; HomoloGene: 11154; GeneCards: MOAP1; OMA:MOAP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.12 Start 93,182,199 bp End 93,184,923 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 E Start 102,708,489 bp End 102,709,920 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus prefrontal cortex Brodmann area 9 primary visual cortex right frontal lobe hypothalamus anterior cingulate cortex cerebellum cerebellar cortex cerebellar hemisphere Top expressed in spermatocyte spermatid neural tube testicle mesencephalon hypothalamus dentate gyrus of hippocampal formation granule cell tail of embryo ganglionic eminence Cortex of frontal lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm mitochondrial outer membrane cytosol mitochondrion Biological process apoptotic process apoptotic signaling pathway positive regulation of release of cytochrome c from mitochondria protein insertion into mitochondrial membrane involved in apoptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64112 64113 Ensembl ENSG00000165943 ENSG00000278268 ENSMUSG00000096458 UniProt Q96BY2 Q9ERH6 RefSeq (mRNA) NM_022151 NM_001142937 NM_022323 RefSeq (protein) NP_071434 NP_001136409 NP_071718 Location (UCSC) Chr 14: 93.18 – 93.18 Mb Chr 12: 102.71 – 102.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Baksh S, Tommasi S, Fenton S, et al. (2005). "The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death". Mol. Cell. 18 (6): 637–50. doi:10.1016/j.molcel.2005.05.010. PMID 15949439.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Vos MD, Dallol A, Eckfeld K, et al. (2006). "The RASSF1A tumor suppressor activates Bax via MOAP-1". J. Biol. Chem. 281 (8): 4557–63. doi:10.1074/jbc.M512128200. PMID 16344548.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Fu NY, Sukumaran SK, Yu VC (2007). "Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10051–6. Bibcode:2007PNAS..10410051F. doi:10.1073/pnas.0700007104. PMC 1877986. PMID 17535899.