MEMO1

MEMO1
Identifiers
Aliases	MEMO1, C2orf4, MEMO, NS5ATP7, CGI-27, mediator of cell motility 1
External IDs	OMIM: 611786; MGI: 1924140; GeneCards: MEMO1
Gene location (Human) Chr. Chromosome 2 (human) Band 2p22.3 Start 31,865,060 bp End 32,011,230 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E2 Start 74,506,031 bp End 74,602,516 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis gastrocnemius muscle monocyte corpus callosum ventricular zone muscle of thigh lymph node mucosa of esophagus left ventricle Top expressed in spermatocyte blood lens spermatid hair follicle tail of embryo seminiferous tubule ventricular zone tibiofemoral joint zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus cytosol Biological process regulation of microtubule-based process regulation of cell motility Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51072 76890 Ensembl ENSG00000162959 ENSMUSG00000058704 UniProt Q9Y316 Q91VH6 RefSeq (mRNA) NM_001137602 NM_015955 NM_001301833 NM_001301852 NM_133771 RefSeq (protein) NP_001131074 NP_001288762 NP_001288781 NP_057039 NP_001358841 NP_001358842 NP_001358843 NP_001358844 NP_001358845 NP_001358846 NP_001358847 NP_001358849 NP_001358850 NP_598532 Location (UCSC) Chr 2: 31.87 – 32.01 Mb Chr 17: 74.51 – 74.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mediator of cell motility 1 is a protein that in humans is encoded by the MEMO1 gene.

Further reading

• Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (March 2009). "Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration". Journal of Cell Science. 122 (Pt 6): 787–97. doi:10.1242/jcs.032094. PMID 19223396.
• Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A (June 2004). "Memo mediates ErbB2-driven cell motility". Nature Cell Biology. 6 (6): 515–22. doi:10.1038/ncb1134. PMID 15156151. S2CID 23073115.
• Reymond A, Friedli M, Henrichsen CN, Chapot F, Deutsch S, Ucla C, Rossier C, Lyle R, Guipponi M, Antonarakis SE (November 2001). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
• Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (February 2008). "Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site". The Journal of Biological Chemistry. 283 (5): 2734–40. doi:10.1074/jbc.M703523200. PMID 18045866.
• Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (June 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A (November 2008). "Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells". The Journal of Cell Biology. 183 (3): 401–8. doi:10.1083/jcb.200805107. PMC 2575782. PMID 18955552.