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3,4-Methylenedioxyphentermine

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(Redirected from MDPH)

MDPH
Clinical data
Other namesMDP; MDPH; 3,4-Methylenedioxyphentermine; 3,4-Methylenedioxy-α,α-dimethylphenethylamine; 3,4-Methylenedioxy-α-methylamphetamine; α-Methyl-MDA
Routes of
administration		Oral[1]
Drug classPsychoactive drug
ATC code
  • None
Pharmacokinetic data
Duration of action3–5 hours[1]
Identifiers
  • 1-(2H-1,3-benzodioxol-5-yl)-2-methylpropan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • NC(C)(C)CC1=CC(OCO2)=C2C=C1
  • InChI=1S/C11H15NO2/c1-11(2,12)6-8-3-4-9-10(5-8)14-7-13-9/h3-5H,6-7,12H2,1-2H3 X markN
  • Key:OIZBHKBNZXRXSM-UHFFFAOYSA-N X markN
 X markNcheckY (what is this?)  (verify)

MDPH, also known as 3,4-methylenedioxyphentermine or as α-methyl-MDA, is a psychoactive drug of the amphetamine family.[1] MDPH was first synthesized by Alexander Shulgin.[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPH.[1]

Use and effects

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In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists MDPH's dose as 160 to 240 mg orally and its duration as 3 to 5 hours.[1] MDPH's effects are very similar to those of MDA: they both are smooth and "stoning," and do not cause any visuals.[1] They also alter dreams and dream patterns.[1] But it is said to have none of the magic of MDMA.[1] Shulgin describes MDPH as a promoter; it promotes the effects of other drugs, similarly to 2C-D.[1]

Chemistry

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Synthesis

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The chemical synthesis of MDPH has been described.[1]

Analogues

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The N-methyl derivative, 3,4-methylenedioxy-N-methylphentermine (MDMPH), has been described by Shulgin as lacking MDMA-like effects.[2] Accordingly, MDMPH, as well as MDPH, were found to be inactive as serotonin releasing agents in vitro.[2][3]

Society and culture

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United Kingdom

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This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.[4]

See also

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References

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  1. 1 2 3 4 5 6 7 8 9 10 11 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. MDPH entry in PiHKAL
  2. 1 2 Nichols DF, Oberlender R (1990). "Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents?". Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA. Topics in the Neurosciences. Vol. 9. Boston, MA: Springer US. pp. 105–131. doi:10.1007/978-1-4613-1485-1_7. ISBN 978-1-4612-8799-5. PMID 1979214.
  3. ↑ Nichols DE, Lloyd DH, Hoffman AJ, Nichols MB, Yim GK (May 1982). "Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes". Journal of Medicinal Chemistry. 25 (5): 530–535. doi:10.1021/jm00347a010. PMID 7086839.
  4. ↑ "UK Misuse of Drugs act 2001 Amendment summary". Isomer Design. Archived from the original on 22 October 2017. Retrieved 12 March 2014.
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