MAG1
 | This article relies on a single source. (November 2020) |
| 3-methyl-adenine DNA glycosylase [Saccharomyces cerevisiae] | |||||||
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| Identifiers | |||||||
| Symbol | MAG1 | ||||||
| NCBI gene | 856885 | ||||||
| UniProt | P22134 | ||||||
| Other data | |||||||
| EC number | 3.2.2.21 | ||||||
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MAG1 is a gene in the yeast Saccharomyces cerevisiae that encodes DNA-3-methyladenine glycosylase, a monofunctional DNA N-glycosylase involved in base excision repair.[1][2][3] It initiates repair of alkylation damage and helps protect yeast cells from methylating agents.[2]
Function
[edit]MAG1 transcription is induced when yeast cells are exposed to relatively non-toxic levels of alkylating agents.[4] The encoded glycosylase has been reported to excise 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine from DNA.[3]
References
[edit]- ↑ "Entrez Gene: MAG1: 3-methyl-adenine DNA glycosylase (Saccharomyces cerevisiae)".
- 1 2 "Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae". PubMed.
- 1 2 "DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae". Genetics.
- ↑ "Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage". PubMed Central (PMC).
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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