IST1 homolog

IST1
Identifiers
Aliases	IST1, OLC1, KIAA0174, ESCRT-III associated factor, CHMP8, IST1 factor associated with ESCRT-III
External IDs	OMIM: 616434; MGI: 1919205; HomoloGene: 8849; GeneCards: IST1; OMA:IST1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FRR, 3FRS, 4U7E, 4U7I, 4U7Y, 4WZX, 3JC1
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.2 Start 71,845,996 bp End 71,931,199 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 110,397,957 bp End 110,419,892 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary gastric mucosa rectum right ovary right uterine tube skin of leg body of uterus skin of abdomen canal of the cervix anterior pituitary Top expressed in transitional epithelium of urinary bladder medullary collecting duct vestibular sensory epithelium stroma of bone marrow superior cervical ganglion hair follicle renal corpuscle pyloric antrum gastric mucosa dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein-containing complex binding protein binding MIT domain binding cadherin binding Cellular component cytoplasm cytosol centrosome Flemming body microtubule organizing center extracellular exosome cytoskeleton cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment midbody nuclear envelope nucleus extracellular region azurophil granule lumen intracellular membrane-bounded organelle chromatin Biological process protein localization viral release from host cell abscission establishment of protein localization viral capsid secondary envelopment multivesicular body assembly cytokinesis positive regulation of collateral sprouting cell division positive regulation of proteolysis protein transport cell cycle ESCRT III complex disassembly neutrophil degranulation cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9798 71955 Ensembl ENSG00000182149 ENSMUSG00000031729 UniProt P53990 Q9CX00 RefSeq (mRNA) NM_014761 NM_001270975 NM_001270976 NM_001270977 NM_001270978 NM_001270979 NM_028018 NM_001361562 RefSeq (protein) NP_001257904 NP_001257905 NP_001257906 NP_001257907 NP_001257908 NP_055576 NP_082294 NP_001348491 Location (UCSC) Chr 16: 71.85 – 71.93 Mb Chr 8: 110.4 – 110.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

IST1 homolog is a protein that in humans is encoded by the IST1 gene (previously KIAA0174). IST1 homolog interacts with the ESCRT (endosomal sorting complexes required for transport), which is involved with vesicle budding and cytokinesis.

Further reading

• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–246. doi:10.1006/excr.2000.4948. PMID 10942595.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human IST1 homolog