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Jay Shendure

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From Wikipedia, the free encyclopedia
Jay Shendure
Born
Solon Edit this on Wikidata
EducationHarvard University, Princeton University, Harvard Medical School Edit this on Wikidata
Occupation
Notable work
Awards
Scientific career
FieldsGenetics Edit this on Wikidata
Workplaces
ThesisMultiplex genome sequencing and analysis (2005)
George Church
Academic advisors
Lee M. Silver
Websitekrishna.gs.washington.edu

Jay Shendure is an American geneticist and professor of genome sciences at the University of Washington. [1] He is known for his work on genomic technologies, including developing DNA-based diagnostic techniques, and one of the earliest successful demonstrations of second-generation DNA sequencing.[2]

Research

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Shendure's research focuses on the applications of genomic technologies and techniques for molecular and developmental biology. In 2005, his doctoral research with George M. Church resulted one of the first successful proof-of-concepts of next-generation DNA sequencing.[3][4][5] Shendure's research group at the University of Washington pioneered exome sequencing and its application to Mendelian disorders,[5][6] a strategy that has been applied to identify hundreds of disease-causing genes.[7] Other notable accomplishments of Shendure's laboratory include the first whole genome sequencing of a human fetus using samples obtained non-invasively from the parents,[8][9] and the sequencing of the HeLa genome in agreement with Henrietta Lacks' family.[10][11][12]

Education and career

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Shendure was born in Solon, Ohio and graduated from Solon High School in 1992.[13] He attended Princeton University where he spent time working in the mouse genetics laboratory of his academic advisor, Lee M. Silver.[14] He graduated summa cum laude in 1996 and studied in Pune, India, on a 1996-1997 Fulbright scholarship.[15] He attended Harvard Medical School as part of the Medical Scientist Training Program, where he received his Ph.D. in 2005 and his M.D. in 2007. [5]

He joined the faculty at the Department of Genome Sciences at the University of Washington in 2007. He was tenured as an associate professor in 2011 and named full professor in 2015.[1] [5]He became the scientific director of the Brotman-Baty Institute in 2017 [16] and in 2023 became the scientific director of the newly-launched Seattle Hub for Synthetic Biology.[17]

Awards and honors

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Shendure is a 2006 recipient of the TR35 Young Innovator Award from MIT Technology Review,[18] the Curt Stern Award from the American Society of Human Genetics in 2012,[19] the FederaPrijs from the Federation of Dutch Medical Scientific Societies in 2013,[20] a National Institutes of Health Director's Pioneer Award in 2013,[21] and a Howard Hughes Medical Investigator Award.

References

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  1. 1 2 "Jay Shendure – UW Genome Sciences". Retrieved 2026-09-12.
  2. ↑ "National Academy of Sciences: Jay Shendure". 2022-05-10. Retrieved 2026-08-30.
  3. ↑ Nicholas Wade. "2 New Methods to Sequence DNA Promise Vastly Lower Costs". The New York Times. Retrieved 2014-02-04.
  4. ↑ "Milestone 18 : Nature Milestones in DNA". Nature. 2007-10-15. Archived from the original on 2014-02-22. Retrieved 2014-02-04.
  5. 1 2 3 4 Eichler, E. E. (2013). "2012 Introduction to the Curt Stern Award: Jay Shendure". The American Journal of Human Genetics. 92 (3): 338–339. doi:10.1016/j.ajhg.2012.11.019. PMC 3591784. PMID 23472755.
  6. ↑ Elie Dolgin (2009-11-13). "Selective sequencing solves a genetic mystery : Nature News". Nature. Retrieved 2014-02-04.
  7. ↑ Jocelyn Kaiser (2010-11-12). "Affordable 'Exomes' Fill Gaps in a Catalog of Rare Diseases". Science. 330 (6006): 903. Bibcode:2010Sci...330..903K. doi:10.1126/science.330.6006.903. PMID 21071642.
  8. ↑ Andrew Pollack. "DNA Blueprint for Fetus Built Using Tests of Parents". The New York Times. Retrieved 2014-02-04.
  9. ↑ Lopatto, Elizabeth (2012-06-06). "Blood-Saliva Analysis May Replace Invasive Prenatal Test". Bloomberg. Retrieved 2014-02-04.
  10. ↑ "After Decades of Research Henrietta Lack's Family is Asked for Consent". The New York Times. Retrieved 2014-02-04.
  11. ↑ "Deal done over HeLa cell line : Nature News & Comment". Nature. 2013-08-07. Retrieved 2014-02-04.
  12. ↑ Hudson, Kathy L.; Collins, Francis S. (2013). "Biospecimen policy: Family matters". Nature. 500 (7461): 141–142. Bibcode:2013Natur.500..141H. doi:10.1038/500141a. PMC 5101952. PMID 23925224.
  13. ↑ Zunt, Dick (1992-05-27). "Solon is Coming on Strong". The Plain Dealer.
  14. ↑ Wimmer, Doris. "Jay Shendure". European Human Genetics Conference. Retrieved 2026-07-27.
  15. ↑ "Scientist who mapped first Indian genome remembers Pune connection". The Indian Express. 2011-01-04.
  16. ↑ "About The Brotman Baty Institute". brotmanbaty.org. Retrieved 2026-08-24.
  17. ↑ Boyle, Alan (2023-12-07). "Seattle Hub for Synthetic Biology plans to transform cells into tiny recording devices". GeekWire. Retrieved 2026-08-14.
  18. ↑ "Innovator Under 35: Jay Shendure, 31 – MIT Technology Review". MIT Technology Review. Archived from the original on September 29, 2009. Retrieved 2014-02-04.
  19. ↑ "American Society of Human Genetics Honors Dr. Jay Shendure with Curt Stern Award for 2012" (PDF). American Society of Human Genetics. Archived from the original (PDF) on 2016-11-09. Retrieved 2014-02-04.
  20. ↑ "Prijswinnaar Federa 2013 | Stichting Federatie van Medisch Wetenschappelijke Verenigingen". Federa.org. Archived from the original on 2014-02-22. Retrieved 2014-02-04.
  21. ↑ "NIH Director's Pioneer Award Program – 2013 PioneerAward Recipients". NIH Common Fund. 2013-12-04. Archived from the original on February 21, 2014. Retrieved 2014-02-04.
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