Isothiazole
| |||
| |||
| Names | |||
|---|---|---|---|
| Preferred IUPAC name
1,2-Thiazole[1] | |||
| Other names
isothiazole | |||
| Identifiers | |||
3D model (JSmol) |
|||
| ChEBI | |||
| ChemSpider | |||
| ECHA InfoCard | 100.241.294 | ||
PubChem CID |
|||
| UNII | |||
CompTox Dashboard (EPA) |
|||
| |||
| |||
| Properties | |||
| C3H3NS | |||
| Molar mass | 85.12 g·mol−1 | ||
| Boiling point | 114 °C (237 °F; 387 K)[2] | ||
| Acidity (pKa) | −0.5 (of conjugate acid)[3] | ||
| Related compounds | |||
Related compounds |
thiazole, isoxazole | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |||
Isothiazole, or 1,2-thiazole, is an organic compound consisting with the formula (CH)3S(N). The ring is unsaturated and features an S-N bond.[4] The isomeric thiazole, where the S and N are not directly bonded are far more common.
Isothiazones are produced by oxidation of enamine-thiones.[5] The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.
See also
[edit]References
[edit]- ↑ International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 140. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
- ↑ Isothiazoles, D. W. Brown and M. Sainsbury, page 513
- ↑ Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978)
- ↑ Heterocyclic Chemistry, 3rd Edition, J.A. Joule, K. Mills, and G.F. Smith, page 394
- ↑ Kaur, Navjeet (2023). "Five-membered S,N-heterocycles". 5-Membered Heterocycle Synthesis Using Iodine. pp. 435–472. doi:10.1016/B978-0-443-18941-8.00007-9. ISBN 9780443189418.
 | This article about a heterocyclic compound is a stub. You can help Wikipedia by adding missing information. |