IRF2BP2

IRF2BP2
Identifiers
Aliases	IRF2BP2, interferon regulatory factor 2 binding protein 2, CVID14
External IDs	OMIM: 615332; MGI: 2443921; HomoloGene: 34290; GeneCards: IRF2BP2; OMA:IRF2BP2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	234,610,178 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	127,320,725 bp
RNA expression pattern
	Top expressed in
	epithelium of lactiferous gland; ; lactiferous duct; ; trachea; ; pancreatic epithelial cell; ; mucosa of paranasal sinus; ; superior surface of tongue; ; pylorus; ; trigeminal ganglion; ; tail of epididymis; ; caput epididymis;
	Top expressed in
	aortic valve; ; ascending aorta; ; molar; ; hand; ; stroma of bone marrow; ; left lung lobe; ; left colon; ; body of femur; ; foot; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated; immature B cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	359948
	270110
	ENSG00000168264
	ENSMUSG00000051495
	Q7Z5L9
	E9Q1P8
	NM_182972; NM_001077397
	NM_001164598
	NP_001070865; NP_892017
	NP_001158070
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene.^[5]

Function

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168264 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051495 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Interferon regulatory factor 2 binding protein 2". Retrieved 2017-01-06.

Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. doi:10.1093/nar/gkg431. PMC 162335. PMID 12799427.
Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. doi:10.1158/0008-5472.CAN-08-2896. PMC 4264605. PMID 19190336.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. doi:10.1128/MCB.00974-10. PMC 3133407. PMID 21576369.
Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE. 6 (8) e24100. Bibcode:2011PLoSO...624100T. doi:10.1371/journal.pone.0024100. PMC 3162591. PMID 21887377.
Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE. 7 (11) e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC 3504151. PMID 23185413.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168264 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interferon regulatory factor 2 binding protein 2". Retrieved 2017-01-06.

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IRF2BP2

Function

References

Further reading