INPP5B

INPP5B
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	OMIM: 147264; MGI: 103257; HomoloGene: 69021; GeneCards: INPP5B; OMA:INPP5B - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTC, 3N9V, 4CML, 5A7J, 5A7I
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.1.3.36 ↗ ↗ ↗ ↗ 3.1.3.56 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 37,860,697 bp End 37,947,057 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 57.89 cM Start 124,635,643 bp End 124,695,304 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary gastric mucosa popliteal artery tibial arteries right coronary artery right ovary ascending aorta granulocyte left coronary artery cerebellar hemisphere Top expressed in right lung lobe neural layer of retina left lung right kidney proximal tubule human kidney granulocyte lobe of cerebellum cerebellar vermis primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity protein binding hydrolase activity GTPase activator activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity inositol phosphate phosphatase activity Cellular component integral component of membrane cytosol endosome phagocytic vesicle membrane Golgi apparatus early endosome membrane membrane plasma membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment cytoplasm Biological process flagellated sperm motility in utero embryonic development inositol phosphate metabolic process regulation of protein processing phosphatidylinositol dephosphorylation spermatogenesis regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3633 16330 Ensembl ENSG00000204084 ENSMUSG00000028894 UniProt P32019 Q8K337 RefSeq (mRNA) NM_001297434 NM_005540 NM_001350227 NM_001350228 NM_008385 RefSeq (protein) NP_001284363 NP_005531 NP_001337156 NP_001337157 NP_001352749 NP_001352750 NP_001352751 NP_001352752 NP_001352753 NP_001352754 NP_032411 Location (UCSC) Chr 1: 37.86 – 37.95 Mb Chr 4: 124.64 – 124.7 Mb PubMed search
Wikidata
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Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Further reading

• Mitchell CA, Connolly TM, Majerus PW (1989). "Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets". J. Biol. Chem. 264 (15): 8873–7. doi:10.1016/S0021-9258(18)81874-9. PMID 2542294.
• Jefferson AB, Majerus PW (1995). "Properties of type II inositol polyphosphate 5-phosphatase". J. Biol. Chem. 270 (16): 9370–7. doi:10.1074/jbc.270.16.9370. PMID 7721860.
• Jänne PA, Dutra AS, Dracopoli NC, et al. (1994). "Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34". Cytogenet. Cell Genet. 66 (3): 164–6. doi:10.1159/000133691. PMID 8125013.
• Speed CJ, Matzaris M, Bird PI, Mitchell CA (1996). "Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase". Eur. J. Biochem. 234 (1): 216–24. doi:10.1111/j.1432-1033.1995.216_c.x. PMID 8529643.
• Jänne PA, Rochelle JM, Martin-DeLeon PA, et al. (1996). "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens". Genomics. 28 (2): 280–5. doi:10.1006/geno.1995.1142. PMID 8530037.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.