IL1RAPL2

IL1RAPL2
Identifiers
Aliases	IL1RAPL2, IL-1R9, IL1R9, IL1RAPL-2, TIGIRR-1, interleukin 1 receptor accessory protein like 2
External IDs	OMIM: 300277; MGI: 1913106; HomoloGene: 9681; GeneCards: IL1RAPL2; OMA:IL1RAPL2 - orthologs
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	105,767,829 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	137,747,695 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; prefrontal cortex; ; right lobe of liver; ; skin of hip; ; Brodmann area 9; ; placenta; ; urinary bladder; ; gallbladder; ; primary visual cortex;
	Top expressed in
	multiform layer of neocortex; ; internal granular layer; ; Purkinje cell; ; external pyramidal layer of neocortex; ; embryo; ; internal pyramidal layer of neocortex; ; barrel cortex; ; primary visual cortex; ; median eminence; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-1, type II, blocking receptor activity; interleukin-1 receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; glutamatergic synapse;
Biological process	central nervous system development; signal transduction; cytokine-mediated signaling pathway; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	26280
	60367
	ENSG00000189108
	ENSMUSG00000059203
	Q9NP60
	Q9ERS6
	NM_017416
	NM_030688
	NP_059112
	NP_109613
	Wikidata
View/Edit Human	View/Edit Mouse

X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the IL1RAPL2 gene.^[5]^[6]

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic intellectual disability.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000189108 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059203 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639. S2CID 22262168.
1 2 "Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2".

Grundtman C, Salomonsson S, Dorph C, et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies". Arthritis Rheum. 56 (2): 674–87. CiteSeerX 10.1.1.489.4969. doi:10.1002/art.22388. PMID 17265504.
Libra M, Mangano K, Anzaldi M, et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders". Oncol. Rep. 15 (5): 1305–8. doi:10.3892/or.15.5.1305. PMID 16596202.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system". Gene. 275 (2): 217–21. doi:10.1016/S0378-1119(01)00659-X. PMID 11587848.
Sana TR, Debets R, Timans JC, et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3". Genomics. 69 (2): 252–62. doi:10.1006/geno.2000.6328. PMID 11031108.
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling". J. Biol. Chem. 275 (39): 29946–54. doi:10.1074/jbc.M004077200. PMID 10882729.
Nagaoka H, Ozawa K, Matsuda F, et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16". Genomics. 22 (1): 189–97. doi:10.1006/geno.1994.1360. PMID 7959766.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000189108 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059203 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10757639-5] Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639. S2CID 22262168.

[entrez-6] 1 2 "Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2".

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IL1RAPL2

References

Further reading