IL1RAP

IL1RAP
Identifiers
Aliases	IL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs	OMIM: 602626; MGI: 104975; HomoloGene: 1643; GeneCards: IL1RAP; OMA:IL1RAP - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O, 4DEP
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.2.2.6 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 3 (human) Band 3q28 Start 190,514,051 bp End 190,659,750 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B2 Start 26,400,454 bp End 26,548,867 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver placenta blood Achilles tendon hair follicle gingival epithelium olfactory zone of nasal mucosa gallbladder germinal epithelium monocyte Top expressed in left lobe of liver lumbar subsegment of spinal cord medial geniculate nucleus dentate gyrus of hippocampal formation granule cell granulocyte medial dorsal nucleus primary oocyte habenula lateral geniculate nucleus spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1 receptor activity protein tyrosine kinase binding interleukin-33 receptor activity signal transducer activity interleukin-1 receptor binding Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane extracellular space glutamatergic synapse Biological process innate immune response inflammatory response immune response signal transduction cytokine-mediated signaling pathway immune system process positive regulation of NF-kappaB transcription factor activity positive regulation of dendrite development interleukin-33-mediated signaling pathway positive regulation of interleukin-13 production positive regulation of interleukin-5 production positive regulation of synapse assembly protein-containing complex assembly interleukin-1-mediated signaling pathway regulation of postsynaptic density assembly trans-synaptic signaling by trans-synaptic complex synaptic membrane adhesion regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3556 16180 Ensembl ENSG00000196083 ENSMUSG00000022514 UniProt Q9NPH3 Q61730 RefSeq (mRNA) NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470 NM_001364879 NM_001364880 NM_001364881 NM_001159317 NM_001159318 NM_008364 NM_134103 RefSeq (protein) NP_001161400 NP_001161401 NP_001161402 NP_001161403 NP_002173 NP_608273 NP_001351808 NP_001351809 NP_001351810 NP_001152789 NP_001152790 NP_032390 NP_598864 Location (UCSC) Chr 3: 190.51 – 190.66 Mb Chr 16: 26.4 – 26.55 Mb PubMed search
Wikidata
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Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.

Interactions

IL1RAP has been shown to interact with TOLLIP and Interleukin 1 receptor, type I.

Further reading

• Greenfeder SA, Nunes P, Kwee L, et al. (1995). "Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex". J. Biol. Chem. 270 (23): 13757–65. doi:10.1074/jbc.270.23.13757. PMID 7775431.
• Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
• Cullinan EB, Kwee L, Nunes P, et al. (1998). "IL-1 receptor accessory protein is an essential component of the IL-1 receptor". J. Immunol. 161 (10): 5614–20. doi:10.4049/jimmunol.161.10.5614. PMID 9820540. S2CID 22101221.
• Lang D, Knop J, Wesche H, et al. (1999). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". J. Immunol. 161 (12): 6871–7. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
• Morton NM, de Groot RP, Cawthorne MA, Emilsson V (1999). "Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells". FEBS Lett. 442 (1): 57–60. Bibcode:1999FEBSL.442...57M. doi:10.1016/S0014-5793(98)01623-8. PMID 9923604. S2CID 81592992.
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi:10.1128/mcb.19.7.4798. PMC 84278. PMID 10373529.
• Jensen LE, Muzio M, Mantovani A, Whitehead AS (2000). "IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein". J. Immunol. 164 (10): 5277–86. doi:10.4049/jimmunol.164.10.5277. PMID 10799889.
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
• Bigonnesse F, Marois M, Maheux R, Akoum A (2001). "Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 7 (4): 333–9. doi:10.1093/molehr/7.4.333. PMID 11279295.
• Jefferies C, Bowie A, Brady G, et al. (2001). "Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1" (PDF). Mol. Cell. Biol. 21 (14): 4544–52. doi:10.1128/MCB.21.14.4544-4552.2001. PMC 87113. PMID 11416133.
• Radons J, Gabler S, Wesche H, et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ruhul Amin AR, Machida K, Oshima K, et al. (2003). "A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling". Oncogene. 21 (57): 8871–8. doi:10.1038/sj.onc.1206018. PMID 12483539. S2CID 29228572.
• Smith DE, Hanna R, Della Friend, et al. (2003). "The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action". Immunity. 18 (1): 87–96. doi:10.1016/S1074-7613(02)00514-9. PMID 12530978.
• Boch JA, Yoshida Y, Koyama Y, et al. (2003). "Characterization of a cascade of protein interactions initiated at the IL-1 receptor". Biochem. Biophys. Res. Commun. 303 (2): 525–31. Bibcode:2003BBRC..303..525B. doi:10.1016/S0006-291X(03)00385-1. PMID 12659850.
• Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Jensen LE, Whitehead AS (2004). "Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis". Cell. Signal. 15 (8): 793–802. doi:10.1016/S0898-6568(03)00039-1. PMID 12781872.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9NPH3 (Human Interleukin-1 receptor accessory protein) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q61730 (Mouse Interleukin-1 receptor accessory protein) at the PDBe-KB.