Hydroperoxide dehydratase

hydroperoxide dehydratase
Identifiers
EC no.	4.2.1.92
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme hydroperoxide dehydratase (EC 4.2.1.92) catalyzes the chemical reaction

(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate $\rightleftharpoons$ (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1U5U​.

References

• Esselman WJ, Clagett CO (1974). "Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed". J. Lipid Res. 15 (2): 173–8. doi:10.1016/S0022-2275(20)36821-8. PMID 4208994.
• Hamberg M (1987). "Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid". Biochim. Biophys. Acta. 920: 76–84. doi:10.1016/0005-2760(87)90313-4.
• Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156 (1): 543–50. Bibcode:1988BBRC..156..543H. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850.