HOTTIP
| HOTTIP | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213, HOXA distal transcript antisense RNA | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614060; GeneCards: HOTTIP | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
In molecular biology, HOTTIP (HOXA transcript at the distal tip) is a long non-coding RNA. The gene encoding HOTTIP is located at the 5′ tip of the HOXA locus, and coordinates the activation of several of the 5′ HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL. This targets the WDR5-MLL complex to the HOXA region and results in H3K4 methylation and transcriptional activation of the HOXA locus.[2] More recently, HOTTIP has been shown to play a role in hepatocellular carcinoma (HCC) progression. HOTTIP expression levels predict metastasis and poor disease outcome in HCC patients. [3] HOTTIP has been shown to be transcriptionally regulated by a transcriptional coactivator PSIP1/p52[4]
See also
[edit]References
[edit]- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (April 2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–124. Bibcode:2011Natur.472..120W. doi:10.1038/nature09819. PMC 3670758. PMID 21423168.
- ↑ Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A, et al. (March 2014). "Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients". Hepatology. 59 (3). Baltimore, Md.: 911–923. doi:10.1002/hep.26740. PMC 3943759. PMID 24114970.
- ↑ Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, et al. (April 2017). "Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip". PLoS Genetics. 13 (4) e1006677. doi:10.1371/journal.pgen.1006677. PMC 5383017. PMID 28384324.
Further reading
[edit]- Burgess DJ (May 2011). "Non-coding RNA: HOTTIP goes the distance". Nature Reviews. Genetics. 12 (5): 300. doi:10.1038/nrg2992. PMID 21483457. S2CID 27802734.