HIV-2 protease
| HIV-2 retropepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.23.47 | ||||||||
| CAS no. | 144114-21-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
HIV-2 protease or retropepsin (EC 3.4.23.47) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Endopeptidase for which the P1 residue is preferably hydrophobic
This enzyme belongs to the peptidase family A2.
References
[edit]- ↑ Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S (April 1991). "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters. 281 (1–2): 77–80. doi:10.1016/0014-5793(91)80362-7. PMID 2015912.
- ↑ Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC (October 1994). "Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry. 269 (42): 26344–8. doi:10.1016/S0021-9258(18)47199-2. PMID 7929352.
External links
[edit]- HIV-2+retropepsin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
