HEXIM2

HEXIM2
Identifiers
Aliases	HEXIM2, L3, hexamethylene bisacetamide inducible 2, HEXIM P-TEFb complex subunit 2
External IDs	OMIM: 615695; MGI: 1918309; HomoloGene: 16946; GeneCards: HEXIM2; OMA:HEXIM2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 45,160,700 bp End 45,170,040 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E1 Start 103,023,255 bp End 103,030,702 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle left testis right testis testicle muscle of thigh gonad pancreatic ductal cell right uterine tube sural nerve apex of heart Top expressed in primary oocyte zygote spermatid spermatocyte secondary oocyte neural layer of retina Rostral migratory stream substantia nigra seminiferous tubule trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cyclin-dependent protein serine/threonine kinase inhibitor activity snRNA binding protein binding 7SK snRNA binding identical protein binding Cellular component nucleoplasm cytoplasm cytosol nuclear speck nucleus Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124790 71059 Ensembl ENSG00000168517 ENSMUSG00000043372 UniProt Q96MH2 Q3TVI4 RefSeq (mRNA) NM_001303436 NM_001303437 NM_001303438 NM_001303439 NM_001303440 NM_001303441 NM_001303442 NM_001303443 NM_001303444 NM_144608 NM_001130515 NM_001130516 NM_027658 RefSeq (protein) NP_001290365 NP_001290366 NP_001290367 NP_001290368 NP_001290369 NP_001290370 NP_001290371 NP_001290372 NP_001290373 NP_653209 NP_001123987 NP_001123988 NP_081934 Location (UCSC) Chr 17: 45.16 – 45.17 Mb Chr 11: 103.02 – 103.03 Mb PubMed search
Wikidata
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Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.

Interactions

HEXIM2 has been shown to interact with P-TEFb at 7SK RNA.

See also

• HEXIM1

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Yik JH, Chen R, Pezda AC, Zhou Q (2005). "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription". J. Biol. Chem. 280 (16): 16368–76. doi:10.1074/jbc.M500912200. PMID 15713661.
• Byers SA, Price JP, Cooper JJ, et al. (2005). "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK". J. Biol. Chem. 280 (16): 16360–7. doi:10.1074/jbc.M500424200. PMID 15713662.
• Li Q, Price JP, Byers SA, et al. (2005). "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186". J. Biol. Chem. 280 (31): 28819–26. doi:10.1074/jbc.M502712200. PMID 15965233.
• Fraldi A, Varrone F, Napolitano G, et al. (2006). "Inhibition of Tat activity by the HEXIM1 protein". Retrovirology. 2 (1): 42. doi:10.1186/1742-4690-2-42. PMC 1183248. PMID 15992410.