GOLPH3

GOLPH3
Identifiers
Aliases	GOLPH3, GOPP1, GPP34, MIDAS, Vps74, golgi phosphoprotein 3
External IDs	OMIM: 612207; MGI: 1913879; HomoloGene: 56942; GeneCards: GOLPH3; OMA:GOLPH3 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KN1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	32,174,319 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	12,351,677 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; epithelium of nasopharynx; ; caput epididymis; ; lactiferous duct; ; tail of epididymis; ; cardia; ; corpus epididymis; ; mucosa of sigmoid colon; ; pylorus; ; lower lobe of lung;
	Top expressed in
	parotid gland; ; epithelium of stomach; ; zygote; ; seminal vesicula; ; decidua; ; submandibular gland; ; lacrimal gland; ; Gonadal ridge; ; pyloric antrum; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-4-phosphate binding; protein binding; enzyme binding; lipid binding;
Cellular component	cytosol; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; Golgi cisterna; mitochondrial intermembrane space; plasma membrane; Golgi cisterna membrane; trans-Golgi network; mitochondrion;
Biological process	cell adhesion molecule production; glycoprotein biosynthetic process; gene expression; Golgi organization; regulation of mitochondrion organization; Golgi vesicle budding; negative regulation of apoptotic process; asymmetric Golgi ribbon formation; protein secretion; positive regulation of protein secretion; leukocyte tethering or rolling; protein transport; cell population proliferation; cell migration; Golgi ribbon formation; positive regulation of TOR signaling; lamellipodium assembly; protein retention in Golgi apparatus; Golgi to plasma membrane protein transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
	64083
	66629
	ENSG00000113384
	ENSMUSG00000022200
	Q9H4A6
	Q9CRA5
	NM_022130
	NM_025673
	NP_071413
	NP_079949
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi phosphoprotein 3 (GOLPH3) is a human protein encoded by GOLPH3 gene. It is a peripheral membrane protein of the Golgi that probably has a regulatory role in Golgi trafficking.^[5]

Clinical significance

Golph 3 expression is associated with poor prognosis of various cancers of gastrointestinal tract, such as gastric and esophageal squamous cell carcinoma.^[6]^[7] Higher expression of GOLPH3 is reported to be associated with greater sensitivity of colorectal cancer to Fluorouracil therapy.^[8]

Notes and references

1 2 3 GRCh38: Ensembl release 89: ENSG00000113384 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022200 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GOLPH3 golgi phosphoprotein 3".
↑ Wang JH (2013). "High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis". PLOS ONE. 7 (10) e45622. Bibcode:2012PLoSO...745622W. doi:10.1371/journal.pone.0045622. PMC 3462781. PMID 23056210.
↑ Hu BS (Feb 2013). "Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer". Tumour Biol. 34 (1): 515–20. doi:10.1007/s13277-012-0576-z. PMID 23132295. S2CID 6309770.
↑ Wang Z (Jan 2014). "GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy". J. Transl. Med. 12 (1): 15. doi:10.1186/1479-5876-12-15. PMC 4029222. PMID 24444035.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113384 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022200 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GOLPH3 golgi phosphoprotein 3".

[pmid_=_23056210-6] Wang JH (2013). "High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis". PLOS ONE. 7 (10) e45622. Bibcode:2012PLoSO...745622W. doi:10.1371/journal.pone.0045622. PMC 3462781. PMID 23056210.

[pmid_=_23132295-7] Hu BS (Feb 2013). "Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer". Tumour Biol. 34 (1): 515–20. doi:10.1007/s13277-012-0576-z. PMID 23132295. S2CID 6309770.

[pmid_=_24444035-8] Wang Z (Jan 2014). "GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy". J. Transl. Med. 12 (1): 15. doi:10.1186/1479-5876-12-15. PMC 4029222. PMID 24444035.

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Clinical significance

Notes and references