FOXS1

FOXS1
Identifiers
Aliases	FOXS1, FKHL18, FREAC10, forkhead box S1
External IDs	OMIM: 602939; MGI: 95546; HomoloGene: 20871; GeneCards: FOXS1; OMA:FOXS1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.21 Start 31,844,303 bp End 31,845,604 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 152,773,818 bp End 152,775,128 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery left coronary artery ascending aorta testicle Descending thoracic aorta popliteal artery tibial arteries apex of heart tibial nerve right auricle of heart Top expressed in external carotid artery internal carotid artery embryo sciatic nerve muscle of thigh Gonadal ridge right kidney stroma of bone marrow spermatocyte endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process blood vessel development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of DNA-binding transcription factor activity neuromuscular process controlling balance transcription, DNA-templated positive regulation of multicellular organism growth negative regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2307 14239 Ensembl ENSG00000179772 ENSMUSG00000074676 UniProt O43638 Q61574 RefSeq (mRNA) NM_004118 NM_010226 RefSeq (protein) NP_004109 NP_034356 Location (UCSC) Chr 20: 31.84 – 31.85 Mb Chr 2: 152.77 – 152.78 Mb PubMed search
Wikidata
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Forkhead box S1 is a protein that in humans is encoded by the FOXS1 gene.

Function

The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008].

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.