FBXO2

FBXO2
Identifiers
Aliases	FBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2
External IDs	OMIM: 607112; MGI: 2446216; HomoloGene: 8132; GeneCards: FBXO2; OMA:FBXO2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,655,785 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,250,881 bp
RNA expression pattern
	Top expressed in
	amygdala; ; C1 segment; ; right frontal lobe; ; anterior cingulate cortex; ; caudate nucleus; ; Brodmann area 9; ; putamen; ; nucleus accumbens; ; right hemisphere of cerebellum; ; prefrontal cortex;
	Top expressed in
	vestibular membrane of cochlear duct; ; utricle; ; vestibular sensory epithelium; ; facial motor nucleus; ; anterior horn of spinal cord; ; optic nerve; ; stria vascularis; ; pontine nuclei; ; medial vestibular nucleus; ; cochlea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amyloid-beta binding; carbohydrate binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase activity;
Cellular component	organelle membrane; membrane; SCF ubiquitin ligase complex; intracellular membrane-bounded organelle; dendritic spine; endoplasmic reticulum; cytosol; cytoplasm;
Biological process	ubiquitin-dependent protein catabolic process; regulation of protein ubiquitination; proteolysis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent ERAD pathway; glycoprotein catabolic process; negative regulation of cell population proliferation; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	26232
	230904
	ENSG00000116661
	ENSMUSG00000041556
	Q9UK22
	Q80UW2
	NM_012168
	NM_176848
	NP_036300
	NP_789818
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.^[5]^[6]^[7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116661 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041556 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
1 2 "Entrez Gene: FBXO2 F-box protein 2".

Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116661 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041556 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-5] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid10531037-6] Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.

[entrez-7] 1 2 "Entrez Gene: FBXO2 F-box protein 2".

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FBXO2

References

Further reading