FAM136A

FAM136A
Identifiers
Aliases	FAM136A, family with sequence similarity 136 member A
External IDs	OMIM: 616275; MGI: 1913738; GeneCards: FAM136A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	70,302,090 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,347,040 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; body of pancreas; ; gingival epithelium; ; rectum; ; mucosa of transverse colon; ; epithelium of nasopharynx; ; hair follicle; ; duodenum; ; right lobe of liver; ; pancreatic epithelial cell;
	Top expressed in
	primitive streak; ; embryo; ; abdominal wall; ; epiblast; ; embryo; ; endocardial cushion; ; yolk sac; ; somite; ; migratory enteric neural crest cell; ; cumulus cell;
	More reference expression data
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	84908
	66488
	ENSG00000035141
	ENSMUSG00000057497
	Q96C01
	Q9CR98
NM_001329752; NM_001329753; NM_001329755; NM_001329757; NM_001329758;
	NM_032822
	NM_025591; NM_001368363
NP_001316681; NP_001316682; NP_001316684; NP_001316686; NP_001316687;
	NP_116211
	NP_079867; NP_001355292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein FAM136A is a protein that in humans is encoded by the FAM136A gene^[5]

Clinical significance

Mutations in FAM136A are associated to Ménière's disease.^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000035141 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057497 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FLJ14668 hypothetical protein FLJ14668".
↑ Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, et al. (2015). "Diagnostic criteria for Menière's disease". Journal of Vestibular Research. 25 (1): 1–7. doi:10.3233/VES-150549. PMID 25882471.
↑ Requena T, Cabrera S, Martín-Sierra C, Price SD, Lysakowski A, Lopez-Escamez JA (February 2015). "Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease". Human Molecular Genetics. 24 (4): 1119–1126. doi:10.1093/hmg/ddu524. PMC 4834881. PMID 25305078.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000035141 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057497 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FLJ14668 hypothetical protein FLJ14668".

[2015DiagConsensus-6] Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, et al. (2015). "Diagnostic criteria for Menière's disease". Journal of Vestibular Research. 25 (1): 1–7. doi:10.3233/VES-150549. PMID 25882471.

[7] Requena T, Cabrera S, Martín-Sierra C, Price SD, Lysakowski A, Lopez-Escamez JA (February 2015). "Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease". Human Molecular Genetics. 24 (4): 1119–1126. doi:10.1093/hmg/ddu524. PMC 4834881. PMID 25305078.

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FAM136A

Clinical significance

References

Further reading