Ets variant 2

ETV2
Identifiers
Aliases	ETV2, ER71, ETSRP71, Ets variant 2, ETS variant transcription factor 2
External IDs	OMIM: 609358; MGI: 99253; HomoloGene: 7308; GeneCards: ETV2; OMA:ETV2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,644,871 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,335,277 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; testicle; ; mucosa of transverse colon; ; stromal cell of endometrium; ; granulocyte; ; right lobe of liver; ; skin of abdomen; ; body of pancreas; ; skin of leg;
	Top expressed in
	embryo; ; urethra; ; male urethra; ; primitive streak; ; morula; ; epiblast; ; embryo; ; seminiferous tubule; ; blastocyst; ; pharynx;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; cell differentiation; positive regulation of endothelial cell differentiation; regulation of transcription, DNA-templated; blood vessel morphogenesis; placenta development; regulation of transcription by RNA polymerase II; mesoderm formation; in utero embryonic development; Wnt signaling pathway; transcription by RNA polymerase II; positive regulation of mesoderm development; positive regulation of gene expression; BMP signaling pathway involved in mesodermal cell fate specification; erythrocyte differentiation; blastocyst development; positive regulation of transcription by RNA polymerase II; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	2116
	14008
	ENSG00000105672
	ENSMUSG00000006311
	O00321
	P41163
	NM_001300974; NM_001304549; NM_014209
	NM_007959
	NP_001287903; NP_001291478; NP_055024
	NP_031985
	Wikidata
View/Edit Human	View/Edit Mouse

Ets variant 2 is a protein that in humans is encoded by the ETV2 gene.^[5] It is a transcription factor and also plays a role in vascular endothelial cell development.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105672 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006311 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ets variant 2".
↑ Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993. PMID 26694034.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105672 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006311 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ets variant 2".

[6] Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993. PMID 26694034.

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References