ERGIC1

ERGIC1
Identifiers
Aliases	ERGIC1, ERGIC-32, ERGIC32, NET24, endoplasmic reticulum-golgi intermediate compartment 1, AMCN, AMC2
External IDs	OMIM: 617946; MGI: 1914708; GeneCards: ERGIC1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	172,952,792 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,656,934 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right adrenal cortex; ; left adrenal cortex; ; mucosa of ileum; ; body of stomach; ; parotid gland; ; decidua; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta;
	Top expressed in
	ascending aorta; ; aortic valve; ; tail of embryo; ; lacrimal gland; ; genital tubercle; ; seminal vesicula; ; condyle; ; external carotid artery; ; salivary gland; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle-mediated transport; transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57222
	67458
	ENSG00000113719
	ENSMUSG00000001576
	Q969X5
	Q9DC16
	NM_001031711; NM_020462
	NM_026170
	NP_001026881
	NP_080446
	Wikidata
View/Edit Human	View/Edit Mouse

Endoplasmic reticulum-Golgi intermediate compartment protein 1 is a protein that in humans is encoded by the ERGIC1 gene.

ERGIC1 is thought to cycle between the endoplasmic reticulum (ER) and Golgi membranes and to participate in bidirectional secretory-pathway protein trafficking.^[5] The protein interacts with related ERGIC proteins and has been reported to promote their turnover. It is predicted to have a multi-pass membrane topology that is consistent its role in membrane organization and cargo transport.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113719 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001576 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Guo Y, Zheng J, Liu L, Li S, Zhang M, Ge L (August 2026). "The ER-Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses". EMBO Reports. doi:10.1038/s44319-026-00908-z. PMID 42632860.
↑ Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, et al. (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–47253. doi:10.1074/jbc.M406644200. PMID 15308636.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113719 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Guo Y, Zheng J, Liu L, Li S, Zhang M, Ge L (August 2026). "The ER-Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses". EMBO Reports. doi:10.1038/s44319-026-00908-z. PMID 42632860.

[6] Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, et al. (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–47253. doi:10.1074/jbc.M406644200. PMID 15308636.

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References