EID2

EID2
Identifiers
Aliases	EID2, CRI2, EID-2, EP300 interacting inhibitor of differentiation 2
External IDs	OMIM: 609773; MGI: 2681174; GeneCards: EID2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,540,161 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,968,697 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; pons; ; cardiac muscle tissue of right atrium; ; cerebellar vermis; ; prefrontal cortex; ; mucosa of ileum; ; postcentral gyrus; ; tibialis anterior muscle; ; superior frontal gyrus; ; Brodmann area 9;
	Top expressed in
	superior cervical ganglion; ; hand; ; trigeminal ganglion; ; dorsomedial hypothalamic nucleus; ; fossa; ; otolith organ; ; utricle; ; condyle; ; suprachiasmatic nucleus; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; SMAD binding;
Cellular component	intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	multicellular organism development; SMAD protein complex assembly; cell differentiation; muscle organ development; transforming growth factor beta receptor complex assembly; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of cell population proliferation; transcription, DNA-templated; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	163126
	386655
	ENSG00000176396
	ENSMUSG00000046058
	Q8N6I1
	Q6X7S9
	NM_153232
	NM_198425
	NP_694964
	NP_940817
	Wikidata
View/Edit Human	View/Edit Mouse

EP300 interacting inhibitor of differentiation 2, also known as EID2, is a human gene.^[5]

Function

The protein encoded by this gene may function as an endogenous suppressor of TGF-beta signaling and inhibits differentiation by blocking the histone acetyltransferase activity of p300, class I histone deacetylase, HDACs. The N-terminal portion of EID-2 was required for the binding to HDACs. This region was also involved in the transcriptional repression and nuclear localization, suggesting the importance of the involvement of HDACs in the EID-2 function. EID-2 inhibits TGF-beta/Smad transcriptional responses. EID-2 interacts constitutively with Smad proteins, and most strongly with Smad3. Stable expression of EID-2 in the TGF-beta1-responsive cell line inhibits endogenous Smad3-Smad4 complex formation and TGF-beta1-induced expression of p21 and p15. EID-2 displays developmentally regulated expression with high levels in adult heart and brain. Overexpression of EID-2 inhibits muscle-specific gene expression through inhibition of MyoD-dependent transcription. This inhibitory effect on gene expression can be explained by EID-2's ability to associate with and inhibit the acetyltransferase activity of p300.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176396 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046058 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ji A, Dao D, Chen J, MacLellan WR (October 2003). "EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD". Gene. 318: 35–43. doi:10.1016/j.gene.2003.06.001. PMID 14585496.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176396 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046058 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14585496-5] Ji A, Dao D, Chen J, MacLellan WR (October 2003). "EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD". Gene. 318: 35–43. doi:10.1016/j.gene.2003.06.001. PMID 14585496.

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Function

References