Auxilin

DNAJC6
Identifiers
Aliases	DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDs	OMIM: 608375; MGI: 1919935; HomoloGene: 8865; GeneCards: DNAJC6; OMA:DNAJC6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,415,871 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,499,996 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; pars compacta; ; pars reticulata; ; orbitofrontal cortex; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; pons; ; inferior olivary nucleus; ; Brodmann area 46;
	Top expressed in
	medial dorsal nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; pontine nuclei; ; medial geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; lateral geniculate nucleus; ; piriform cortex; ; primary motor cortex; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; SH3 domain binding; phosphoprotein phosphatase activity; hydrolase activity; clathrin binding;
Cellular component	cytosol; synapse; vesicle; postsynaptic density; cytoplasm; intracellular membrane-bounded organelle; presynapse;
Biological process	peptidyl-tyrosine dephosphorylation; regulation of clathrin-dependent endocytosis; protein dephosphorylation; clathrin coat disassembly; receptor-mediated endocytosis; membrane organization; synaptic vesicle uncoating; clathrin-dependent endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9829
	72685
	ENSG00000116675
	ENSMUSG00000028528
	O75061
	Q80TZ3
	NM_001256864; NM_001256865; NM_014787
NM_001164583; NM_001164584; NM_001164585; NM_198412; NM_001355179;
	NM_001355180
	NP_001243793; NP_001243794; NP_055602
NP_001158055; NP_001158056; NP_001158057; NP_940804; NP_001342108;
	NP_001342109
	Wikidata
View/Edit Human	View/Edit Mouse

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.^[5]^[6]^[7]

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).^[7]

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.^[8] The phosphatase domain belongs to the auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.^[9]^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116675 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028528 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
↑ Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 11 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
↑ Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.
↑ "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.
↑ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

External links

Human DNAJC6 genome location and DNAJC6 gene details page in the UCSC Genome Browser.

Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.
Scheele U, Kalthoff C, Ungewickell E (September 2001). "Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex". The Journal of Biological Chemistry. 276 (39): 36131–8. doi:10.1074/jbc.M106511200. PMID 11470803.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116675 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028528 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.

[pmid11147971-6] Ohtsuka K, Hata M (April 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 11 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

[entrez-7] 1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".

[8] Haynie DT, Xue B (May 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24 (5): 874–82. doi:10.1002/pro.2664. PMC 4420535. PMID 25694109.

[9] "Phosphatase Subfamily Auxilin - PhosphataseWiki". phosphatome.net.

[10] Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling. 10 (474) eaag1796. doi:10.1126/scisignal.aag1796. PMID 28400531. S2CID 41041971.

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Auxilin

Function

Structure

References

External links

Further reading