DNAJB9

DNAJB9
Identifiers
Aliases	DNAJB9, ERdj4, MDG-1, MDG1, MST049, MSTP049, DnaJ heat shock protein family (Hsp40) member B9
External IDs	OMIM: 602634; MGI: 1351618; HomoloGene: 32155; GeneCards: DNAJB9; OMA:DNAJB9 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CTR
Gene location (Human)
Chr.	Chromosome 7 (human)
End	108,574,850 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	44,257,109 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; cartilage tissue; ; body of pancreas; ; kidney tubule; ; beta cell; ; germinal epithelium; ; corpus epididymis; ; glomerulus; ; decidua; ; metanephric glomerulus;
	Top expressed in
	seminal vesicula; ; islet of Langerhans; ; gastrula; ; olfactory epithelium; ; decidua; ; parotid gland; ; ciliary body; ; median eminence; ; paraventricular nucleus of hypothalamus; ; supraoptic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	misfolded protein binding; protein binding; Hsp70 protein binding; chaperone binding;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; nucleolus; endoplasmic reticulum; cytoplasm;
Biological process	IRE1-mediated unfolded protein response; ubiquitin-dependent ERAD pathway; immunoglobulin production; response to unfolded protein; B cell differentiation; response to endoplasmic reticulum stress; negative regulation of IRE1-mediated unfolded protein response;
	Sources:Amigo / QuickGO
Orthologs
	4189
	27362
	ENSG00000128590
	ENSMUSG00000014905
	Q9UBS3
	Q9QYI6
	NM_012328
	NM_013760
	NP_036460
	NP_038788
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128590 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014905 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Prols F, Liehr T, Rinke R, Rautenstrauss B (Apr 1998). "Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2→q24.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 149–50. doi:10.1159/000134706. PMID 9533036.
↑ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
↑ "Entrez Gene: DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9".

Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Pröls F, Mayer MP, Renner O, Czarnecki PG, Ast M, Gässler C, et al. (2001). "Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis". Exp. Cell Res. 269 (1): 42–53. doi:10.1006/excr.2001.5294. PMID 11525638.
Shen Y, Meunier L, Hendershot LM (2002). "Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress". J. Biol. Chem. 277 (18): 15947–56. doi:10.1074/jbc.M112214200. PMID 11836248.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Berger BJ, Müller TS, Buschmann IR, Peters K, Kirsch M, Christ B, et al. (2003). "High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells". Exp. Cell Res. 290 (1): 82–92. doi:10.1016/S0014-4827(03)00316-1. PMID 14516790.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lin KT, Lu RM, Tarn WY (2004). "The WW Domain-Containing Proteins Interact with the Early Spliceosome and Participate in Pre-mRNA Splicing In Vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128590 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014905 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9533036-5] Prols F, Liehr T, Rinke R, Rautenstrauss B (Apr 1998). "Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2→q24.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 149–50. doi:10.1159/000134706. PMID 9533036.

[pmid11147971-6] Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

[entrez-7] "Entrez Gene: DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

This page was redesigned at the edge.

DNAJB9

References

Further reading