Cimlanod

Cimlanod
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name N-Hydroxy-5-methylfuran-2-sulfonamide;
CAS Number	1620330-72-4;
PubChem CID	76685198;
DrugBank	DB14983;
ChemSpider	68007456;
UNII	2US4FK1EPV;
KEGG	D11407;
ChEMBL	ChEMBL4297915;
CompTox Dashboard (EPA)	DTXSID801288087 ;
Chemical and physical data
Formula	C5H7NO4S
Molar mass	177.17 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC=C(O1)S(=O)(=O)NO;
	InChI InChI=1S/C5H7NO4S/c1-4-2-3-5(10-4)11(8,9)6-7/h2-3,6-7H,1H3; Key:LIXKIXWSKOENAB-UHFFFAOYSA-N;

Cimlanod (development codes CXL-1427 and BMS-986231) is an experimental drug for the treatment of acute decompensated heart failure. It was discovered by Cardioxyl Pharmaceuticals, which was acquired by Bristol-Myers Squibb. It is a precursor of nitroxyl.^[1]

Cimlanod is a prodrug of CXL-1020.^[2]

A preliminary study showed efficacy in patients with class III and IV heart failure.^[3] A phase II clinical trial was completed in 2016.^[4]

References

↑ "BMS 986231". AdisInsight. Springer Nature Switzerland AG. Retrieved 2017-05-22. Alternative Names: BMS-986231; CXL 1427; HNO Donor
↑ "CXL 1020". AdisInsight. Springer Nature Switzerland AG. Retrieved 2017-05-22.
↑ Zoler ML (22 May 2016). "Nitroxyl prodrug shows promise in acute heart failure".
↑ Clinical trial number NCT02157506 for "A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure" at ClinicalTrials.gov

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