Carbapenam
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| Names | |
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| IUPAC name
1-Azabicyclo[3.2.0]heptan-7-one | |
| Identifiers | |
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3D model (JSmol) |
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| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C6H9NO | |
| Molar mass | 111.144 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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A carbapenam is the parent member of the β-lactams compounds. The parent is of only of theoretical interest, but substituted derivatives are important carbapenem antibiotics, originally inspired by the structure of penicillin. In penicillin, the five-membered ring contains sulfur, whereas carbapenams have a CH2 in place of S. A related class of antibiotics are unsaturated carbapenems.[1] Carbapenam-based antibiotics are widely used, but resistant strains of some pathogens have emerged.[2]
References
[edit]- ↑ Dalhoff, A.; Janjic, N.; Echols, R. (2006). "Redefining penems". Biochemical Pharmacology. 71 (7): 1085–1095. doi:10.1016/j.bcp.2005.12.003. PMID 16413506.
- ↑ Chen, Ying; Fang, Li; Yang, Yunxing; Yan, Rushuang; Fu, Ying; Shen, Ping; Zhao, Dongdong; Chen, Yan; Hua, Xiaoting; Jiang, Yan; Moran, Robert A.; Van Schaik, Willem; Yu, Yunsong (2021). "Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla OXA-48-like genes in China". Journal of Medical Microbiology. 70 (3). doi:10.1099/jmm.0.001306. PMC 8346730. PMID 33507142.
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