CNOT9

CNOT9
Identifiers
Aliases	CNOT9, CT129, RCD-1, RCD1, CAF40, RQCD1, CCR4-NOT transcription complex subunit 9
External IDs	OMIM: 612054; MGI: 1928902; HomoloGene: 3973; GeneCards: CNOT9; OMA:CNOT9 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FV2, 4CRU, 4CRV, 4CT6, 4CT7
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 218,568,580 bp End 218,597,080 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C4 Start 74,545,217 bp End 74,570,001 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium epithelium of nasopharynx ganglionic eminence right uterine tube lymph node stromal cell of endometrium gastric mucosa Achilles tendon anterior pituitary rectum Top expressed in tail of embryo genital tubercle yolk sac epiblast somite ventricular zone maxillary prominence zygote mandibular prominence fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity protein domain specific binding protein binding epidermal growth factor receptor binding kinase binding Cellular component cytoplasm cytosol membrane CCR4-NOT complex P-body CCR4-NOT core complex nucleus protein-containing complex Biological process nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation regulation of transcription, DNA-templated mRNA catabolic process cytokine-mediated signaling pathway sex differentiation transcription, DNA-templated gene silencing negative regulation of intracellular estrogen receptor signaling pathway regulation of translation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of peptidyl-serine phosphorylation positive regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9125 58184 Ensembl ENSG00000144580 ENSMUSG00000026174 UniProt Q92600 Q9JKY0 RefSeq (mRNA) NM_001271634 NM_001271635 NM_005444 NM_021383 RefSeq (protein) NP_001258563 NP_001258564 NP_005435 NP_067358 Location (UCSC) Chr 2: 218.57 – 218.6 Mb Chr 1: 74.55 – 74.57 Mb PubMed search
Wikidata
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CCR4-NOT transcription complex subunit 9 is a protein that in humans is encoded by the CNOT9 gene.

Function

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-Not deadenylation complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].

Further reading

• Hiroi N, Ito T, Yamamoto H, Ochiya T, Jinno S, Okayama H (October 2002). "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation". EMBO J. 21 (19): 5235–44. doi:10.1093/emboj/cdf521. PMC 129043. PMID 12356739.
• Garapaty S, Mahajan MA, Samuels HH (March 2008). "Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1". J. Biol. Chem. 283 (11): 6806–16. doi:10.1074/jbc.M706986200. PMID 18180299.
• Ajiro M, Katagiri T, Ueda K, Nakagawa H, Fukukawa C, Lin ML, Park JH, Nishidate T, Daigo Y, Nakamura Y (October 2009). "Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells". Int. J. Oncol. 35 (4): 673–81. PMID 19724902.
• Ajiro M, Nishidate T, Katagiri T, Nakamura Y (November 2010). "Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis". Int. J. Oncol. 37 (5): 1085–93. doi:10.3892/ijo_00000760. PMID 20878056.
• Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W (June 2014). "Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression". Mol. Cell. 54 (5): 751–65. doi:10.1016/j.molcel.2014.03.036. PMID 24768538.
• Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E (June 2014). "A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing". Mol. Cell. 54 (5): 737–50. doi:10.1016/j.molcel.2014.03.034. PMID 24768540.
• Wong SQ, Behren A, Mar VJ, Woods K, Li J, Martin C, Sheppard KE, Wolfe R, Kelly J, Cebon J, Dobrovic A, McArthur GA (January 2015). "Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma". Oncotarget. 6 (2): 1115–27. doi:10.18632/oncotarget.2747. PMC 4359221. PMID 25544760.
• Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE (March 2018). "Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment" (PDF). J. Mol. Biol. 430 (5): 722–736. doi:10.1016/j.jmb.2017.12.018. PMID 29291391.
• Han J, Yu J, Dai Y, Li J, Guo M, Song J, Zhou X (February 2019). "Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway". Bosn J Basic Med Sci. 19 (1): 52–59. doi:10.17305/bjbms.2018.3399. PMC 6387672. PMID 29924958.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.