CNOT4

CNOT4
Identifiers
Aliases	CNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDs	OMIM: 604911; MGI: 1859026; HomoloGene: 40870; GeneCards: CNOT4; OMA:CNOT4 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4U, 1UR6
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 7 (human) Band 7q33 Start 135,361,795 bp End 135,510,127 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B1 Start 34,999,000 bp End 35,110,659 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon testicle gastrocnemius muscle parietal pleura corpus callosum internal globus pallidus sural nerve endothelial cell muscle of thigh Top expressed in genital tubercle Rostral migratory stream tail of embryo zygote saccule primary oocyte secondary oocyte otic placode fossa otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding nucleic acid binding metal ion binding transferase activity RNA binding Cellular component cytosol cytoplasm CCR4-NOT complex nucleus Biological process protein ubiquitination nuclear-transcribed mRNA poly(A) tail shortening protein autoubiquitination DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ubiquitin-dependent protein catabolic process regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4850 53621 Ensembl ENSG00000080802 ENSMUSG00000038784 UniProt O95628 Q8BT14 RefSeq (mRNA) NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316 NM_001393370 NM_001393371 NM_001393372 NM_001393373 NM_001393374 NM_001393375 NM_001164411 NM_001164412 NM_001164413 NM_001164414 NM_016877 RefSeq (protein) NP_001008226 NP_001177776 NP_001177777 NP_001177778 NP_001177779 NP_037448 NP_001157883 NP_001157884 NP_001157885 NP_001157886 NP_058573 Location (UCSC) Chr 7: 135.36 – 135.51 Mb Chr 6: 35 – 35.11 Mb PubMed search
Wikidata
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CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.

Further reading

• Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038. S2CID 25618632.
• Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
• Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits" (PDF). The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
• Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
• Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
• Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
• Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.