CEP192
Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.[5][6] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.[7]
Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.[7] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.[8]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000101639 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024542 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: centrosomal protein 192kDa".
- ↑ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–574. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
- 1 2 Zhu F, Lawo S, Bird A, Pinchev D, Ralph A, Richter C, et al. (January 2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology. 18 (2): 136–141. Bibcode:2008CBio...18..136Z. doi:10.1016/j.cub.2007.12.055. PMID 18207742. S2CID 16159409.
- ↑ Gomez-Ferreria MA, Rath U, Buster DW, Chanda SK, Caldwell JS, Rines DR, et al. (November 2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology. 17 (22): 1960–1966. Bibcode:2007CBio...17.1960G. doi:10.1016/j.cub.2007.10.019. PMID 17980596. S2CID 10245690.
External links
[edit]Further reading
[edit]- Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.
- Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". The Journal of Cell Biology. 129 (6): 1617–1628. doi:10.1083/jcb.129.6.1617. PMC 2291169. PMID 7790358.
- Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA (November 2000). "The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion". The Journal of Cell Biology. 151 (4): 837–846. doi:10.1083/jcb.151.4.837. PMC 2169446. PMID 11076968.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
- Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–3245. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
- Casenghi M, Meraldi P, Weinhart U, Duncan PI, Körner R, Nigg EA (July 2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Developmental Cell. 5 (1): 113–125. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
- Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R (April 2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation". EMBO Reports. 7 (4): 418–424. doi:10.1038/sj.embor.7400639. PMC 1456919. PMID 16462731.
- Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology. 94 (1–3): 203–208. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
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