CDCA3

CDCA3
Identifiers
Aliases	CDCA3, GRCC8, TOME-1, cell division cycle associated 3, TOME1
External IDs	OMIM: 607749; MGI: 1315198; HomoloGene: 8403; GeneCards: CDCA3; OMA:CDCA3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,851,292 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,810,664 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; oocyte; ; secondary oocyte; ; gonad; ; left testis; ; right testis; ; ganglionic eminence; ; duodenum; ; jejunal mucosa; ; mucosa of transverse colon;
	Top expressed in
	ventricular zone; ; fetal liver hematopoietic progenitor cell; ; medial ganglionic eminence; ; genital tubercle; ; tibiofemoral joint; ; spermatid; ; tail of embryo; ; seminiferous tubule; ; spermatocyte; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; cytoplasm;
Biological process	cell division; cell cycle; protein ubiquitination; biological process;
	Sources:Amigo / QuickGO
Orthologs
	83461
	14793
	ENSG00000111665
	ENSMUSG00000023505
	Q99618
	Q99M54
	NM_001297602; NM_001297603; NM_001297604; NM_031299; NM_001331019
	NM_013538
	NP_001284531; NP_001284532; NP_001284533; NP_001317948; NP_112589
	NP_038566
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle-associated protein 3 is a protein that in humans is encoded by the CDCA3 gene.^[5]^[6]^[7]

Interactions

CDCA3 has been shown to interact with SKP1A.^[8]

1 2 3 GRCh38: Ensembl release 89: ENSG00000111665 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023505 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA (May 1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
↑ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
↑ "Entrez Gene: CDCA3 cell division cycle associated 3".
↑ Ayad, Nagi G; Rankin Susannah; Murakami Monica; Jebanathirajah Judith; Gygi Steven; Kirschner Marc W (Apr 2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1). United States: 101–13. doi:10.1016/S0092-8674(03)00232-0. ISSN 0092-8674. PMID 12679038.

Human CDCA3 genome location and CDCA3 gene details page in the UCSC Genome Browser.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yoshida K (2005). "Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters". FEBS Lett. 579 (6): 1488–92. doi:10.1016/j.febslet.2005.01.055. PMID 15733861. S2CID 19511881.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ayad NG, Rankin S, Murakami M, et al. (2003). "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC". Cell. 113 (1): 101–13. CiteSeerX 10.1.1.522.1877. doi:10.1016/S0092-8674(03)00232-0. PMID 12679038.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.

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