Phenylethylidenehydrazine

Phenylethylidenehydrazine
Clinical data
Drug class	GABA-T inhibitor
ATC code	None;
Legal status
Legal status	In general: uncontrolled;
Pharmacokinetic data
Elimination half-life	~12 hours[citation needed]
Identifiers
	IUPAC name (1E)-(2-Phenylethylidene)hydrazine;
CAS Number	29443-41-2 ;
PubChem CID	10103216;
ChemSpider	8278744;
UNII	9FZ4W7J6VE;
CompTox Dashboard (EPA)	DTXSID20435557 ;
Chemical and physical data
Formula	C8H10N2
Molar mass	134.182 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N/N=C/CC1=CC=CC=C1;

Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or as β-phenylethylidenehydrazine, is a GABA transaminase inhibitor.^[1]^[2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.^[1] PEH may contribute to phenelzine's anxiolytic effects.^[3]

References

1 2 Parent MB, Master S, Kashlub S, Baker GB (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". Biochemical Pharmacology. 63 (1): 57–64. doi:10.1016/S0006-2952(01)00856-5. PMID 11754874.
↑ Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience. 126 (2): 423–432. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360. S2CID 30625470.
↑ Baker GB, Wong JT, Yeung JM, Coutts RT (March 1991). "Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA)". Journal of Affective Disorders. 21 (3): 207–211. doi:10.1016/0165-0327(91)90041-p. ISSN 0165-0327. PMID 1648582.