Basopenia
| Basopenia | |
|---|---|
 | |
| A peripheral blood basophil stained with a Romanovsky stain. | |
| Specialty | Hematology  |
Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.[1] It has been proposed as an indicator of ovulation.[2] It is difficult to detect without flow cytometry, because normal levels are so low.[3] It can be defined as less than 0.01 billion / L.[4] Basopenia has been observed in a number of conditions, including after the administration of corticosteroids and in disease states such as chronic urticaria and lupus.[5]
Mechanism
[edit]Basophils, which are granulocytes, account for only a small proportion of the total leukocyte count, and are responsible for controlling the immune response during parasitic infections[6]. In case of activation, basophils can secrete histamine, proteoglycans (e.g. heparin and chondroitin), leukotrienes (LTD-4), and several cytokines[7]. Although there is a positive correlation between higher basophil counts and high blood histamine concentrations, this correlation is not indicative of cause and effect.[8]
Associated conditions
[edit]- Hereditary absence of basophils (very rare)
- Elevated levels of glucocorticoids
- Hyperthyroidism or treatment with thyroid hormones
- Ovulation
- Hypersensitivity reactions
- urticaria[9][10][11]
- Anaphylaxis
- Drug-induced reactions
- Leukocytosis (in association with diverse disorders)
References
[edit]- ↑ "Definition: basophilic leukopenia from Online Medical Dictionary".
- ↑ Soni R, Bose S, Gada D, Potnis V (October 1996). "Basopenia as an indicator of ovulation (a short term clinical study)". Indian J. Physiol. Pharmacol. 40 (4): 385–8. PMID 9055113.
- ↑ "CLS_3223_Unit 03_WBC". Archived from the original on 2009-01-30.
- ↑ "Pathology".
- ↑ Shah, Hemali; Eisenbarth, Stephanie; Tormey, Christopher A; Siddon, Alexa J (January 1, 2021). "Behind the scenes with basophils: an emerging therapeutic target". Immunotherapy Advances. 1 (1) ltab008. Oxford University Press (OUP). doi:10.1093/immadv/ltab008. ISSN 2732-4303. PMC 9327101. PMID 35919744.
- ↑ Voehringer D (December 2009). "The role of basophils in helminth infection". Trends in Parasitology. 25 (12): 551–6. doi:10.1016/j.pt.2009.09.004. PMID 19782643.
- ↑ Janeway CA Jr.; et al. (2001). Immunobiology (electronic full text via NCBI Bookshelf) (5th ed.). Garland Publishing. ISBN 978-0-8153-3642-6.
- ↑ "Basophil count". Nursing Critical Care. 14 (4). Ovid Technologies (Wolters Kluwer Health): 35. 2019. doi:10.1097/01.ccn.0000559778.07144.9d. ISSN 1558-447X. Retrieved November 16, 2023.
- ↑ Lourenço FD, Azor MH, Santos JC (May 2008). "Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-IgE stimulus". Br. J. Dermatol. 158 (5): 979–86. doi:10.1111/j.1365-2133.2008.08499.x. PMID 18341658. S2CID 2935740.
- ↑ Grattan CE, Dawn G, Gibbs S, Francis DM (March 2003). "Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity". Clin. Exp. Allergy. 33 (3): 337–41. doi:10.1046/j.1365-2222.2003.01589.x. PMID 12614448. S2CID 30477970.
- ↑ Grattan CE, Walpole D, Francis DM (December 1997). "Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity". Clin. Exp. Allergy. 27 (12): 1417–24. doi:10.1046/j.1365-2222.1997.1630972.x. PMID 9433937.