B115
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| Names | |
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| IUPAC name
1-Methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine | |
| Identifiers | |
3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
PubChem CID |
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| Properties | |
| C18H19N | |
| Molar mass | 249.357 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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B115 (IUPAC name 1-methyl-4-[(E)-2-naphthalen-1-ylethenyl]-3,6-dihydro-2H-pyridine[1]) is an inhibitor of the enzyme choline acetyltransferase (ChAT).
In vivo activity
[edit]B115 inhibits human ChAT with an IC50 of 4.3 μM.[2] During in vivo testing, B115 has been found to partially protect against soman, a nerve agent, but it has been suggested that this may not be due to ChAT inhibition.[3][4]
References
[edit]- ↑ PubChem. "1-Methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-01-02.
- ↑ "AID 52122 - Inhibition of choline acetyltransferase (CAT) enzyme - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-01-02.
- ↑ Gray, A. P.; Platz, R. D.; Henderson, T. R.; Chang, T. C.; Takahashi, K.; Dretchen, K. L. (April 1, 1988). "Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes". Journal of Medicinal Chemistry. 31 (4): 807–814. doi:10.1021/jm00399a022. ISSN 0022-2623. PMID 3351860.
- ↑ Henderson, T. R.; Gray, A. P.; Platz, R. D.; Kellar, K. J.; Dretchen, K. L. (1991). "Inhibition of brain choline acetyltransferase in vivo: (E)-1-methyl-4-(1-naphthylvinyl)-1,2,3,6-tetrahydropyridine hydrochloride (B115), a depot form of a potent inhibitor". Toxicology and Applied Pharmacology. 107 (2): 336–343. Bibcode:1991ToxAP.107..336H. doi:10.1016/0041-008x(91)90213-x. ISSN 0041-008X. PMID 1994515.