ATAD3B

ATAD3B
Alliases	TOB3, AAA-TOB3, KIAA 1273
External IDs	NCBI: AAH02542.1
Gene Location (Human)

ATAD3B
Identifiers
Aliases	ATAD3B, AAA-TOB3, TOB3, ATPase family, AAA domain containing 3B, ATPase family AAA domain containing 3B
External IDs	OMIM: 612317; HomoloGene: 121829; GeneCards: ATAD3B; OMA:ATAD3B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,497,848 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; sural nerve; ; mucosa of transverse colon; ; granulocyte; ; right lobe of thyroid gland; ; mucosa of ileum; ; right hemisphere of cerebellum; ; skin of leg; ; left ovary; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding; zinc ion binding;
Cellular component	membrane; mitochondrial inner membrane; mitochondrion; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	neutrophil degranulation; mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
	83858
	n/a
	ENSG00000160072
	n/a
	Q5T9A4
	n/a
	NM_031921; NM_001317238
	n/a
	NP_001304167; NP_114127
	n/a
	Wikidata
View/Edit Human

ATPase family AAA domain-containing protein 3B (or ATAD3B) is a protein that in humans is encoded by the ATAD3B gene.^[3] ATAD3 is part of the AAA protein family.^[3] The function of ATAD3B is not yet well understood by the scientific community.

Function

ATAD3B is associated with the mitochondria. The C terminus is anchored in the mitochondrial inter membrane space.^[4]

The protein is linked with the pluripotency of stem cells. The ATAD3A gene is targeted by c-Myc^[4] which is one of four factors needed to create induced pluripotent stem (i-PS) cells from mouse embryonic fibroblasts(MEFs).^[5]

Its expression is linked to cell cycle function and tumor growth.^[6] When ATAD3B was overexpressed, cell duplication took an extra three hours by spending a longer time in G1 phase.^[6] Abnormal expression levels of ATAD3B has been linked to chemoresistance. Overexpression of ATAD3B was the found to be the strongest factor in breast cancer survival rates.^[7]

Characteristics

A mutation in the stop codon means that ATAD3B has a 62 amino acid longer UTR.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160072 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Q5T9A4 · ATD3B_HUMAN". uniprot.org. UniProt consortium.
1 2 Merle, Nicolas; Féraud, Olivier; Gilquin, Benoit; Hubstenberger, Arnaud; Kieffer-Jacquinot, Sylvie; Assard, Nicole; Bennaceur-Griscelli, Annelise; Honnorat, Jérôme; Baudier, Jacques (2012-07-01). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A". Mitochondrion. 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. ISSN 1567-7249. PMID 22664726.
↑ Takahashi, Kazutoshi; Yamanaka, Shinya (2006-08-25). "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors". Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. hdl:2433/159777. ISSN 0092-8674. PMID 16904174. S2CID 1565219.
1 2 Hubstenberger, Arnaud; Labourdette, Gérard; Baudier, Jacques; Rousseau, Denis (2008-09-10). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties". Experimental Cell Research. 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. ISSN 0014-4827. PMID 18639545.
↑ Ovaska, Kristian; Matarese, Filomena; Grote, Korbinian; Charapitsa, Iryna; Cervera, Alejandra; Liu, Chengyu; Reid, George; Seifert, Martin; Stunnenberg, Hendrik G.; Hautaniemi, Sampsa (2013-06-20). Tucker-Kellogg, Greg (ed.). "Integrative Analysis of Deep Sequencing Data Identifies Estrogen Receptor Early Response Genes and Links ATAD3B to Poor Survival in Breast Cancer". PLOS Computational Biology. 9 (6) e1003100. Bibcode:2013PLSCB...9E3100O. doi:10.1371/journal.pcbi.1003100. ISSN 1553-7358. PMC 3688481. PMID 23818839.
↑ Li, Shuijie; Rousseau, Denis (2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression". Journal of Bioenergetics and Biomembranes. 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. ISSN 0145-479X. PMID 22318359. S2CID 11106754.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160072 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-3] 1 2 "Q5T9A4 · ATD3B_HUMAN". uniprot.org. UniProt consortium.

[:0-4] 1 2 Merle, Nicolas; Féraud, Olivier; Gilquin, Benoit; Hubstenberger, Arnaud; Kieffer-Jacquinot, Sylvie; Assard, Nicole; Bennaceur-Griscelli, Annelise; Honnorat, Jérôme; Baudier, Jacques (2012-07-01). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A". Mitochondrion. 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. ISSN 1567-7249. PMID 22664726.

[5] Takahashi, Kazutoshi; Yamanaka, Shinya (2006-08-25). "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors". Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. hdl:2433/159777. ISSN 0092-8674. PMID 16904174. S2CID 1565219.

[:1-6] 1 2 Hubstenberger, Arnaud; Labourdette, Gérard; Baudier, Jacques; Rousseau, Denis (2008-09-10). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties". Experimental Cell Research. 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. ISSN 0014-4827. PMID 18639545.

[7] Ovaska, Kristian; Matarese, Filomena; Grote, Korbinian; Charapitsa, Iryna; Cervera, Alejandra; Liu, Chengyu; Reid, George; Seifert, Martin; Stunnenberg, Hendrik G.; Hautaniemi, Sampsa (2013-06-20). Tucker-Kellogg, Greg (ed.). "Integrative Analysis of Deep Sequencing Data Identifies Estrogen Receptor Early Response Genes and Links ATAD3B to Poor Survival in Breast Cancer". PLOS Computational Biology. 9 (6) e1003100. Bibcode:2013PLSCB...9E3100O. doi:10.1371/journal.pcbi.1003100. ISSN 1553-7358. PMC 3688481. PMID 23818839.

[8] Li, Shuijie; Rousseau, Denis (2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression". Journal of Bioenergetics and Biomembranes. 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. ISSN 0145-479X. PMID 22318359. S2CID 11106754.

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Function

Characteristics

References