ARPP-21

ARPP21
Identifiers
Aliases	ARPP21, ARPP-21, R3HDM3, RCS, TARPP, cAMP regulated phosphoprotein 21kDa, cAMP regulated phosphoprotein 21
External IDs	OMIM: 605488; MGI: 107562; HomoloGene: 32306; GeneCards: ARPP21; OMA:ARPP21 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p22.3 Start 35,638,945 bp End 35,794,496 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F3|9 62.46 cM Start 112,065,091 bp End 112,235,938 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus putamen nucleus accumbens caudate nucleus middle temporal gyrus cerebellar hemisphere right hemisphere of cerebellum primary visual cortex Brodmann area 23 right frontal lobe Top expressed in olfactory tubercle globus pallidus piriform cortex nucleus accumbens superior frontal gyrus temporal lobe cingulate gyrus visual cortex primary motor cortex amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function calmodulin binding nucleic acid binding molecular function Cellular component cytoplasm cellular component Biological process cellular response to heat biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10777 74100 Ensembl ENSG00000172995 ENSMUSG00000032503 UniProt Q9UBL0 Q9DCB4 RefSeq (mRNA) NM_001025068 NM_001025069 NM_001267616 NM_001267617 NM_001267618 NM_001267619 NM_016300 NM_198399 NM_001177615 NM_001177616 NM_001177617 NM_001177618 NM_001177619 NM_001177620 NM_001177623 NM_028755 NM_033264 RefSeq (protein) NP_001020239 NP_001020240 NP_001254545 NP_001254546 NP_001254547 NP_001254548 NP_057384 NP_938409 NP_001171086 NP_001171087 NP_001171088 NP_001171089 NP_001171090 NP_001171091 NP_001171094 NP_083031 NP_150289 NP_001348929 NP_001348930 NP_001348931 NP_001348932 NP_001348933 NP_001348934 NP_001348935 NP_001348936 NP_001348937 NP_001348938 NP_001348939 NP_001348940 NP_001348941 NP_001348942 NP_001348943 NP_001348944 NP_001348945 NP_001348946 NP_001348947 NP_001348948 NP_001348949 NP_001348950 NP_001348951 NP_001348952 NP_001348953 NP_001348954 NP_001348955 NP_001348956 NP_001348957 NP_001348958 NP_001348959 NP_001348960 NP_001348961 NP_001348962 NP_001348963 NP_001348964 NP_001348965 NP_001348966 NP_001348967 NP_001348968 NP_001348969 NP_001348970 Location (UCSC) Chr 3: 35.64 – 35.79 Mb Chr 9: 112.07 – 112.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cyclic AMP-regulated phosphoprotein, 21 kDa, also known as ARPP21, is a human gene. Research published in March 2026 identified ARPP21 as one of the genes contributing to overall risk of developing amyotrophic lateral sclerosis (ALS). A new high-impact ARPP21 variant was identified (p.P747L). Furthermore, the p.P563L mutation, previously established as the cause of ALS in seven unrelated families from Spain, was confirmed to be associated with a more aggressive disease course.

External links

• Human ARPP21 genome location and ARPP21 gene details page in the UCSC Genome Browser.

Further reading

• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–2772. doi:10.1021/ac035352d. PMID 15144186.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
• Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P (2004). "A network of control mediated by regulator of calcium/calmodulin-dependent signaling". Science. 306 (5696): 698–701. Bibcode:2004Sci...306..698R. doi:10.1126/science.1099961. PMID 15499021. S2CID 12127149.
• Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC, Nairn AC, Greengard P (2000). "Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia". Neuropharmacology. 39 (9): 1637–44. doi:10.1016/s0028-3908(99)00230-0. PMID 10854908. S2CID 11927459.
• Nair AG, Bhalla US, Hellgren Kotaleski J (2016). "Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration". PLOS Comput Biol. 12 (9) e1005080. Bibcode:2016PLSCB..12E5080N. doi:10.1371/journal.pcbi.1005080. PMC 5008828. PMID 27584878.