ANAPC5

ANAPC5
Identifiers
Aliases	ANAPC5, APC5, anaphase promoting complex subunit 5
External IDs	OMIM: 606948; MGI: 1929722; GeneCards: ANAPC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G05, 5G04
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,399,896 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,959,402 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; bronchial epithelial cell; ; tibia; ; canal of the cervix; ; skin of hip; ; body of uterus; ; corpus callosum; ; tibial nerve; ; right ovary;
	Top expressed in
	fossa; ; condyle; ; internal carotid artery; ; external carotid artery; ; fetal liver hematopoietic progenitor cell; ; Paneth cell; ; superior cervical ganglion; ; hair follicle; ; trigeminal ganglion; ; vas deferens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase binding; ubiquitin protein ligase activity;
Cellular component	nucleoplasm; cytosol; nucleus; anaphase-promoting complex;
Biological process	cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51433
	59008
	ENSG00000089053
	ENSMUSG00000029472
	Q9UJX4
	Q8BTZ4
	NM_001137559; NM_016237; NM_001330489
NM_001042491; NM_001289517; NM_001289518; NM_001289519; NM_001289520;
	NM_021505
	NP_001131031; NP_001317418; NP_057321
NP_001035956; NP_001276446; NP_001276447; NP_001276448; NP_001276449;
	NP_067480
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.^[5]^[6]

The anaphase-promoting complex (APC) consists of at least eight protein subunits, including ANAPC5 (this gene) , CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM]^[6]

Interactions

ANAPC5 has been shown to interact with ANAPC1,^[7]^[8] ANAPC4,^[7] CDC27^[7]^[9]^[10] and PABPC1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354). New York, N.Y.: 1219–1222. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
1 2 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
1 2 3 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
1 2 Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation". Molecular and Cellular Biology. 24 (9): 3577–3587. doi:10.1128/MCB.24.9.3577-3587.2004. PMC 387753. PMID 15082755.
↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

External links

Human ANAPC5 genome location and ANAPC5 gene details page in the UCSC Genome Browser.

Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–14507. doi:10.1074/jbc.274.20.14500. PMID 10318877.
Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (September 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11317–11322. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. (December 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". The EMBO Journal. 22 (24): 6598–6609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715). New York, N.Y.: 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, et al. (December 2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–695. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID 16319895. S2CID 4432156.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Yu_1998-5] Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354). New York, N.Y.: 1219–1222. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.

[entrez-6] 1 2 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".

[Vodermaier_2003-7] 1 2 3 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–1468. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.

[Sumara_2000-8] Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–762. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

[Koloteva-Levine_2004-9] 1 2 Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation". Molecular and Cellular Biology. 24 (9): 3577–3587. doi:10.1128/MCB.24.9.3577-3587.2004. PMC 387753. PMID 15082755.

[Gmachl_2000-10] Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8978. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

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ANAPC5

Interactions

References

External links

Further reading