AMY1C
| AMY1C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | AMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 104702; GeneCards: AMY1C | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Alpha-amylase 1C is a digestive enzyme that in humans is encoded by the gene AMY1C. [3][4] This saliva enzyme functions to initiate the break down of starch and other carbohydrates.[5] AMY1C is one of a collection of nearby human genes (including AMY1A and AMY1B) that encode identical saliva alpha-amylase proteins, with the exact number of genes varying from individual to individual.[5][6]
Function
[edit]Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary glands (AMY1A, AMY1B, AMY1C)[6] or pancreas (AMY2A, AMY2B).[6] This gene encodes an amylase isoenzyme produced by the salivary gland.[3] See also Amylase § Evolution.
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.
- ↑ Hariharan R, Mousa A, de Courten B (June 2021). "Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence". Obesity Reviews. 22 (6) e13205. doi:10.1111/obr.13205. PMID 33432778.
- 1 2 "Alpha-amylase 1C". uniprot.org. UniProt consortium. Retrieved 2026-09-13.
- 1 2 3 Butterworth PJ, Warren FJ, Ellis PR (July 2011). "Human α‐amylase and starch digestion: An interesting marriage". Starch‐Stärke. 63 (7): 395–405. doi:10.1002/star.201000150.
External links
[edit]- Overview of all the structural information available in the PDB for UniProt: P04745 (Human Alpha-amylase 1) at the PDBe-KB.
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