AMY1C

AMY1C
Identifiers
Aliases	AMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C
External IDs	OMIM: 104702; HomoloGene: 133998; GeneCards: AMY1C; OMA:AMY1C - orthologs
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	103,758,726 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; testicle; ; olfactory zone of nasal mucosa; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; right lung; ; upper lobe of left lung; ; left testis;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; alpha-amylase activity; hydrolase activity; catalytic activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; cation binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	digestion; metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	278
	n/a
	ENSG00000187733
	n/a
	P04745
	n/a
	NM_001008219; NM_001346780
	n/a
	NP_001008220; NP_001333709; NP_001008222; NP_004029; NP_001008219
	n/a
	Wikidata
View/Edit Human

The human AMY1C gene encodes the protein Amylase, alpha 1C (salivary). ^[3]^[4]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland.^[5] See also Amylase § Evolution.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.
↑ Hariharan R, Mousa A, de Courten B (June 2021). "Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence". Obesity Reviews. 22 (6) e13205. doi:10.1111/obr.13205. PMID 33432778.
↑ [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: AK313275.1 [ECO:0000332] ##RefSeq-Attributes-END##

Overview of all the structural information available in the PDB for UniProt: P04745 (Human Alpha-amylase 1) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.