AHCYL1

AHCYL1
Identifiers
Aliases	AHCYL1, DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA, adenosylhomocysteinase like 1
External IDs	OMIM: 607826; MGI: 2385184; HomoloGene: 77353; GeneCards: AHCYL1; OMA:AHCYL1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MTG
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,023,742 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,603,876 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; ventral tegmental area; ; superior vestibular nucleus; ; dorsal motor nucleus of vagus nerve; ; pars reticulata; ; internal globus pallidus; ; subthalamic nucleus; ; pars compacta; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	central gray substance of midbrain; ; CA3 field; ; perirhinal cortex; ; anterior horn of spinal cord; ; entorhinal cortex; ; superior colliculus; ; neural layer of retina; ; nucleus of stria terminalis; ; medulla oblongata; ; inferior colliculi;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	adenosylhomocysteinase activity; protein binding; RNA binding; identical protein binding;
Cellular component	intracellular membrane-bounded organelle; cytosol; extracellular exosome; membrane; endoplasmic reticulum; plasma membrane; cytoplasm; endoplasmic reticulum membrane; apical plasma membrane;
Biological process	protein export from nucleus; regulation of ion transmembrane transporter activity; regulation of anion transport; S-adenosylmethionine cycle; response to calcium ion; mRNA polyadenylation; one-carbon metabolic process; regulation of cardiac conduction; positive regulation of sodium ion transport; epithelial fluid transport; regulation of mRNA 3'-end processing; angiotensin-activated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10768
	229709
	ENSG00000168710
	ENSMUSG00000027893
	O43865
	Q80SW1
	NM_001242673; NM_001242674; NM_001242675; NM_001242676; NM_006621
	NM_145542; NM_001357110; NM_001357111; NM_001357112; NM_001357113
	NP_001229602; NP_001229603; NP_001229604; NP_001229605; NP_006612
	NP_663517; NP_001344039; NP_001344040; NP_001344041; NP_001344042
	Wikidata
View/Edit Human	View/Edit Mouse

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene.^[5]^[6]^[7]^[8]

Interactions

AHCYL1 has been shown to interact with ITPR1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168710 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027893 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics. 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675. S2CID 21593928.
↑ Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem. 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.
1 2 Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
↑ "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

External links

Human AHCYL1 genome location and AHCYL1 gene details page in the UCSC Genome Browser.

Pawlak A, Toussaint C, Lévy I, et al. (1995). "Characterization of a large population of mRNAs from human testis". Genomics. 26 (1): 151–8. doi:10.1016/0888-7543(95)80096-5. PMID 7782076.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Cleaver JE, Afzal V, Feeney L, et al. (1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant". Cancer Res. 59 (5): 1102–8. PMID 10070969.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Shirakabe K, Priori G, Yamada H, et al. (2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1)". Proc. Natl. Acad. Sci. U.S.A. 103 (25): 9542–7. doi:10.1073/pnas.0602250103. PMC 1480443. PMID 16769890.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168710 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027893 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11904675-5] Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics. 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675. S2CID 21593928.

[pmid16754674-6] Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem. 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.

[pmid12525476-7] 1 2 Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.

[entrez-8] "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

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AHCYL1

Interactions

References

External links

Further reading