ADAMTS14

ADAMTS14
Identifiers
Aliases	ADAMTS14, ADAM metallopeptidase with thrombospondin type 1 motif 14
External IDs	OMIM: 607506; MGI: 2179942; GeneCards: ADAMTS14
Gene location (Human)
Chr.	Chromosome 10 (human)
End	70,762,441 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	61,109,217 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; vena cava; ; mucosa of transverse colon; ; putamen; ; appendix; ; tibial nerve; ; sural nerve; ; lateral nuclear group of thalamus; ; inferior ganglion of vagus nerve; ; pars compacta;
	Top expressed in
	zone of skin; ; lip; ; morula; ; white adipose tissue; ; placenta; ; esophagus; ; uterus; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	extracellular region;
Biological process	collagen catabolic process; proteolysis; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	140766
	237360
	ENSG00000138316
	ENSMUSG00000059901
	Q8WXS8
	n/a
	NM_080722; NM_139155
	NM_001081127
	NP_542453; NP_631894
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

ADAMTS14 encodes a member of the ADAMTS protein family. Family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The proteolytic process of the encoded preproprotein generates a mature enzyme. The enzyme cleaves the amino-propeptides of fibrillar collagens, enabling collagen fibril formation before the assembly of collagen, a major extracellular matrix (ECM) protein.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138316 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059901 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-19. This article incorporates text from this source, which is in the public domain.
↑ "ADAMTS14 Gene - GeneCards | ATS14 Protein | ATS14 Antibody". www.genecards.org. Retrieved 2022-05-19.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138316 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059901 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-19. This article incorporates text from this source, which is in the public domain.

[6] "ADAMTS14 Gene - GeneCards | ATS14 Protein | ATS14 Antibody". www.genecards.org. Retrieved 2022-05-19.

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References